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Peptide record

TPDB72195

Neurotoxin standard
76 amino acids
Basic Information
3D PDB MODEL
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TPDB72195
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 76-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MRFYIGLMAALMLTSILRTDSASVDQTGAEGGLALIERVIRQRDAADVKPVARTNEGPGRDPAPCCQHPIETCCRR
Physicochemical Analysis
C349H582N110O108S7
W
AR
8271.55
7.85
11
9
29
+1
19.15
-0.183
83.55
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
21.04
17
Residue Composition
number
9
A
9
R
1
N
5
D
4
C
4
E
3
Q
6
G
1
H
5
I
6
L
1
K
3
M
1
F
5
P
3
S
5
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 9 R: 9 N: 1 D: 5 C: 4 E: 4 Q: 3 G: 6 H: 1 I: 5 L: 6 K: 1 M: 3 F: 1 P: 5 S: 3 T: 5 W: 0 Y: 1 V: 4
Chemical Descriptors
76
C349H582N110O108S7
8271.55
7.85
+1
19.15
-0.183
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion channels. {ECO:0000305}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Probable neurotoxin with unknown target. Possibly targets ion channels..
Conotoxin Cal5a L1 [Cleaved into: Conotoxin Cal5b L1 Conotoxin Cal5.1]
cone snail
Evidence at protein level
Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:21172372}.
Additional Detail Fields 6 fields
Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Conotoxin Cal5a L1 [Cleaved into: Conotoxin Cal5b L1 Conotoxin Cal5.1]
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:21172372}.
cone snail