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Peptide record

TPDB72194

Neurotoxin standard
88 amino acids
Basic Information
3D PDB MODEL
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TPDB72194
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 88-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSSGGLLLLLGLLTLWEVLTPVSSKDRPKFCHLPPKPGPCRAAIPRFYYNPHSKQCEKFIYGGCHGNANSFKTPDECNYTCLGVSLPK
Physicochemical Analysis
C439H680N116O119S7
L
9711.35
8.82
13
5
30
+5
9.63
-0.209
75.34
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11835
121.87
26
Residue Composition
number
3
A
3
R
4
N
2
D
6
C
3
E
1
Q
8
G
3
H
2
I
12
L
7
K
1
M
4
F
10
P
7
S
4
T
1
W
4
Y
3
V
Amino Acid Distribution
A: 3 R: 3 N: 4 D: 2 C: 6 E: 3 Q: 1 G: 8 H: 3 I: 2 L: 12 K: 7 M: 1 F: 4 P: 10 S: 7 T: 4 W: 1 Y: 4 V: 3
Chemical Descriptors
88
C439H680N116O119S7
9711.35
8.82
+5
9.63
-0.209
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Heterotrimer: blocks the voltage-dependent L-type calcium channels (Cav) from the heart, and the small conductance calcium-activated potassium channels (KCa) in the chromaffin cells and in the brain. Is very toxic to mice. FUNCTION: Monomer: serine protease inhibitor that inhibits plasma kallikrein (Ki=0.057 nM), tissue kallikrein (Ki=0.23 nM), trypsin (Ki=0.31 nM), plasmin (Ki=6.1 nM), elastase (Ki=201 nM), factor Xa (Ki=871 nM), alpha-factor XIIa (Ki=2380 nM). Does not inhibit APC, urokinase-type plasminogen activator (uPA/PLAU), tissue plasminogen activator (tPA/PLAT), thrombin and factor VIIa. In addition, the monomer inhibits fibrinolysis in whole blood and prolonged the intrinsec clotting time.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)
Neurotoxin Calcium channel impairing toxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated calcium channel impairing toxin
Heterotrimer: blocks the voltage-dependent L-type calcium channels (Cav) from the heart, and the small conductance calcium-activated potassium channels (KCa) in the chromaffin cells and in the brain. Is very toxic to mice. FUNCTION: Monomer: serine protease inhibitor that inhibits plasma kallikrein (Ki=0.057 nM), tissue kallikrein (Ki=0.23 nM), trypsin (Ki=0.31 nM), plasmin (Ki=6.1 nM), elastase (Ki=201 nM), factor Xa (Ki=871 nM), alpha-factor XIIa (Ki=2380 nM).
Kunitz-type serine protease inhibitor taicotoxin (Taicatoxin, serine protease inhibitor component) (TCX) (TSPI) (Venom protease inhibitor 1) (Venom protease inhibitor 2)
snake
Venom Kunitz-type family
Evidence at protein level
Blood coagulation cascade inhibiting toxin Calcium channel impairing toxin Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Hemostasis impairing toxin Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Protease inhibitor Secreted Serine protease inhibitor Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:1485334}.
Additional Detail Fields 7 fields
Blood coagulation cascade inhibiting toxin Calcium channel impairing toxin Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Hemostasis impairing toxin Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Protease inhibitor Secreted Serine protease inhibitor Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Venom Kunitz-type family
Kunitz-type serine protease inhibitor taicotoxin (Taicatoxin, serine protease inhibitor component) (TCX) (TSPI) (Venom protease inhibitor 1) (Venom protease inhibitor 2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:1485334}.
snake