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Peptide record

TPDB72192

Neurotoxin standard
70 amino acids
Basic Information
3D PDB MODEL
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TPDB72192
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 70-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
LVVSVTSRRVRFWDDFERDENFEEERPYLRNVKRACNDYKSSSYCRSVGSRNECGIHKYRMYCRKTCGSC
Physicochemical Analysis
C358H558N114O110S7
Q
R
8443.49
8.82
16
10
20
+5
21.56
-1.013
43.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
13325
157.81
25
Residue Composition
number
1
A
11
R
4
N
4
D
6
C
6
E
0
Q
3
G
1
H
1
I
2
L
4
K
1
M
3
F
1
P
8
S
2
T
1
W
5
Y
6
V
Amino Acid Distribution
A: 1 R: 11 N: 4 D: 4 C: 6 E: 6 Q: 0 G: 3 H: 1 I: 1 L: 2 K: 4 M: 1 F: 3 P: 1 S: 8 T: 2 W: 1 Y: 5 V: 6
Chemical Descriptors
70
C358H558N114O110S7
8443.49
8.82
+5
21.56
-1.013
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels (Kv1/KCNA). {ECO:0000250|UniProtKB:P29186}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia viridis (Snakelocks anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits voltage-gated potassium channels (Kv1/KCNA)..
U-actitoxin-Avd11a (U-AITX-Avd11a) (Potassium channel toxin avtx-11)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at transcript level
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
U-actitoxin-Avd11a (U-AITX-Avd11a) (Potassium channel toxin avtx-11)
sea anemone