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Peptide record

TPDB72191

Neurotoxin standard
62 amino acids
Basic Information
3D PDB MODEL
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TPDB72191
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 62-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MQKLFIVFVLFCILRLDAEVDGRTATFCTQSICEESCKRQNKNGRCVIEAEGSLIYHLCKCY
Physicochemical Analysis
C312H501N85O90S8
PW
C
7139.41
7.56
9
7
25
+1
10.69
0.177
92.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
46.99
20
Residue Composition
number
3
A
4
R
2
N
2
D
7
C
5
E
3
Q
3
G
1
H
5
I
6
L
4
K
1
M
4
F
0
P
3
S
3
T
0
W
2
Y
4
V
Amino Acid Distribution
A: 3 R: 4 N: 2 D: 2 C: 7 E: 5 Q: 3 G: 3 H: 1 I: 5 L: 6 K: 4 M: 1 F: 4 P: 0 S: 3 T: 3 W: 0 Y: 2 V: 4
Chemical Descriptors
62
C312H501N85O90S8
7139.41
7.56
+1
10.69
0.177
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: May block potassium channels.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
May block potassium channels.
Potassium channel toxin alpha-KTx 22.1 (Neurotoxin BmK38) (Toxin Kcugx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 22 subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at transcript level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 22 subfamily
Potassium channel toxin alpha-KTx 22.1 (Neurotoxin BmK38) (Toxin Kcugx)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion