TPDB

3D PDB MODEL

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TPDB ID TPDB72178

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 318-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MIKKRNTTKISVIGAGSVGATTAYALMLSGVATEIVLVDVNKSKTEGEAMDLSHGADFVKPVNILSGDYKDTEGSDIVVITAGAAQKVGETRLQLINKNINIFKSIIPQVVKYNKDAILLVVSNPVDVLSYVTYKLSGFPKERVIGSGTVLDTSRLKHEIGKRYKIDPRNVNTYIMGEHGDSEIATWSVTNIQNIKIDEYANKENLEYNDNFRKEVYENVKNAAYEVINRKGATFYAIALAVTRIVKAILGDEKTILPVSTLVENYYGIKDVYLGMPCIVGGSGIEKALSIDLNKTEASKLVKSAETLKNTLNNASCL

FASTA

>TPDB72178|Neurotoxin|length=318
MIKKRNTTKISVIGAGSVGATTAYALMLSGVATEIVLVDVNKSKTEGEAMDLSHGADFVKPVNILSGDYKDTEGSDIVVITAGAAQKVGETRLQLINKNINIFKSIIPQVVKYNKDAILLVVSNPVDVLSYVTYKLSGFPKERVIGSGTVLDTSRLKHEIGKRYKIDPRNVNTYIMGEHGDSEIATWSVTNIQNIKIDEYANKENLEYNDNFRKEVYENVKNAAYEVINRKGATFYAIALAVTRIVKAILGDEKTILPVSTLVENYYGIKDVYLGMPCIVGGSGIEKALSIDLNKTEASKLVKSAETLKNTLNNASCL

Formula C1548H2522N410O477S7

Absent Amino Acids

Common Amino Acids V

Mass 34733.93

PI 8.81

Basic Residues 42

Acidic Residues 36

Hydrophobic Residues 137

Net Charge +3

Boman Index 73.17

Hydrophobicity -0.088

Aliphatic Index 104.18

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 27975

Absorbance 280nm 80.54

Polar Residues 88

number

24

A

9

R

24

N

16

D

2

C

20

E

4

Q

23

G

3

H

30

I

25

L

30

K

5

M

5

F

7

P

21

S

22

T

1

W

15

Y

32

V

Amino Acid Distribution

A: 24 R: 9 N: 24 D: 16 C: 2 E: 20 Q: 4 G: 23 H: 3 I: 30 L: 25 K: 30 M: 5 F: 5 P: 7 S: 21 T: 22 W: 1 Y: 15 V: 32

Length

318

Formula

C1548H2522N410O477S7

Mass

34733.93

PI

8.81

Net Charge

+3

Boman Index

73.17

Hydrophobicity

-0.088

Evidence 1 Activity

Source & Reference

Database Source NA