TPDB

3D PDB MODEL

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TPDB ID TPDB72177

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 307-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MISAKMVKDLREKTGAGMMDCKKALTECDGDLEKAVEVLREKGLAAAAKKSGRVAAEGIVSTYISEDMKNGSIVEFNCETDFVSVNELFVELANNLSKQAAFSNVSTAEELLEEKYIADESKLVKDVITELIAKLGENMNLRRIAKLSVDKGVITSYIHGGGRIGVLVKLACEKEDAKLAEIAKDVAMQVAATNPLFLNRDGVDTDTLEKEKEIYRVQALNEGKPEKVVEKMVMGRINKYYKENCLVEQLWVKNGDYTITKYLQEQSKEIGADITVEAFVRYEKGEGIEKKEEDFAEEVQRQMNQGK

FASTA

>TPDB72177|Neurotoxin|length=307
MISAKMVKDLREKTGAGMMDCKKALTECDGDLEKAVEVLREKGLAAAAKKSGRVAAEGIVSTYISEDMKNGSIVEFNCETDFVSVNELFVELANNLSKQAAFSNVSTAEELLEEKYIADESKLVKDVITELIAKLGENMNLRRIAKLSVDKGVITSYIHGGGRIGVLVKLACEKEDAKLAEIAKDVAMQVAATNPLFLNRDGVDTDTLEKEKEIYRVQALNEGKPEKVVEKMVMGRINKYYKENCLVEQLWVKNGDYTITKYLQEQSKEIGADITVEAFVRYEKGEGIEKKEEDFAEEVQRQMNQGK

Formula C1495H2448N402O479S15

Absent Amino Acids

Common Amino Acids E

Mass 34199.19

PI 4.87

Basic Residues 47

Acidic Residues 56

Hydrophobic Residues 126

Net Charge -10

Boman Index 116.25

Hydrophobicity -0.384

Aliphatic Index 90.20

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 19160

Absorbance 280nm 56.02

Polar Residues 64

number

28

A

11

R

15

N

17

D

5

C

39

E

9

Q

21

G

1

H

18

I

25

L

35

K

10

M

7

F

2

P

13

S

13

T

1

W

9

Y

28

V

Amino Acid Distribution

A: 28 R: 11 N: 15 D: 17 C: 5 E: 39 Q: 9 G: 21 H: 1 I: 18 L: 25 K: 35 M: 10 F: 7 P: 2 S: 13 T: 13 W: 1 Y: 9 V: 28

Length

307

Formula

C1495H2448N402O479S15

Mass

34199.19

PI

4.87

Net Charge

-10

Boman Index

116.25

Hydrophobicity

-0.384

Evidence 1 Activity

Source & Reference

Database Source NA