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Peptide record

TPDB72176

Neurotoxin standard
91 amino acids
Basic Information
3D PDB MODEL
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TPDB72176
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 91-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MVATNRCCVFALLFALLLVHSLTEAGKGKEILGKIKEKIIEAKDKMKAGWERLTSQSEYACPAIDKFCEDHCAAKKAVGKCDDFKCNCIKL
Physicochemical Analysis
C445H729N119O126S10
K
10083.01
8.30
18
12
38
+4
22.24
0.000
89.12
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
74.28
18
Residue Composition
number
11
A
2
R
2
N
5
D
8
C
7
E
1
Q
5
G
2
H
6
I
9
L
14
K
2
M
4
F
1
P
3
S
3
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 11 R: 2 N: 2 D: 5 C: 8 E: 7 Q: 1 G: 5 H: 2 I: 6 L: 9 K: 14 M: 2 F: 4 P: 1 S: 3 T: 3 W: 1 Y: 1 V: 4
Chemical Descriptors
91
C445H729N119O126S10
10083.01
8.30
+4
22.24
0.000
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: [Ts19 fragment I]: May function as a voltage-gated potassium channel blocker and may have cytolytic activity (Ref.3). Is often not detected in the tested venom fractions, suggesting that the toxin is likely subject to frequent processing within the venom (PubMed:26116782). {ECO:0000269|Ref.3, ECO:0000305|PubMed:26116782}. FUNCTION: [Ts19 fragment II]: Specific and reversible blocker of the potassium channel Kv1.2/KCNA2 (IC(50)=544 nM). {ECO:0000269|PubMed:26116782}. FUNCTION: [Ts19 fragment III]: Shows cytolytic effects on erythrocytes and induces non-selective pore formation when high concentrations (300 nM) are applied on oocytes. {ECO:0000269|PubMed:26116782}. FUNCTION: [Cryptide TyPep-17]: Does not cause hemolysis, mast cell degranulation, LDH release, and does not have antimicrobial activity. Does not cause edema and pain. {ECO:0000269|PubMed:38408354}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus serrulatus (Brazilian yellow scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
[Ts19 fragment I]: May function as a voltage-gated potassium channel blocker and may have cytolytic activity (Ref.3). Is often not detected in the tested venom fractions, suggesting that the toxin is likely subject to frequent processing within the venom (PubMed:26116782).. FUNCTION: [Ts19 fragment II]: Specific and reversible blocker of the potassium channel Kv1.2/KCNA2 (IC(50)=544 nM).. FUNCTION: [Ts19 fragment III]: Shows cytolytic effects on erythrocytes and induces non-selective pore formation when high concentrations (300 nM) are applied on oocytes.. FUNCTION: [Cryptide TyPep-17]: Doe
Tityustoxin-19 (Ts19) (Potassium channel toxin beta-Ktx 2) [Cleaved into: Cryptide TyPep-17 Ts19 fragment I (Potassium channel toxin beta-Ktx 2-1) Ts19 fragment II (Ts19 Frag-II) (Potassium channel toxin beta-Ktx 2-2) Ts19 fragment III (Ts19 Frag-III)]
scorpion
Long chain scorpion toxin family, Class 2 subfamily
Evidence at protein level
Cytolysis Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18718845}.
Additional Detail Fields 7 fields
Cytolysis Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Long chain scorpion toxin family, Class 2 subfamily
Tityustoxin-19 (Ts19) (Potassium channel toxin beta-Ktx 2) [Cleaved into: Cryptide TyPep-17 Ts19 fragment I (Potassium channel toxin beta-Ktx 2-1) Ts19 fragment II (Ts19 Frag-II) (Potassium channel toxin beta-Ktx 2-2) Ts19 fragment III (Ts19 Frag-III)]
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18718845}.
scorpion