TPDB

3D PDB MODEL

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TPDB ID TPDB72174

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 209-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MKKAILGKKLGMTQIFNENGKVIPVTVIEAGPCTVIQKKTVEKDGYEAIQVAFGDIREKLRNKPIKGHFAKAGVSVKRHIKEFKLEDSNSLEIGQEIKADVFEAGERVDISGVSKGKGFQGTIRRWNAHRGPMSHGSKFHRAVGSMGASSDPSRTFKNKRMPGHMGNVNTTVLNLEVVRIIPEKNLILIKGGVPGPNKGLVQIRNTVKA

FASTA

>TPDB72174|Neurotoxin|length=209
MKKAILGKKLGMTQIFNENGKVIPVTVIEAGPCTVIQKKTVEKDGYEAIQVAFGDIREKLRNKPIKGHFAKAGVSVKRHIKEFKLEDSNSLEIGQEIKADVFEAGERVDISGVSKGKGFQGTIRRWNAHRGPMSHGSKFHRAVGSMGASSDPSRTFKNKRMPGHMGNVNTTVLNLEVVRIIPEKNLILIKGGVPGPNKGLVQIRNTVKA

Formula C1011H1671N301O287S7

Absent Amino Acids

Common Amino Acids K

Mass 22859.65

PI 10.68

Basic Residues 43

Acidic Residues 19

Hydrophobic Residues 75

Net Charge +19

Boman Index 64.03

Hydrophobicity -0.406

Aliphatic Index 84.35

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 30.58

Polar Residues 40

number

12

A

12

R

12

N

6

D

1

C

13

E

6

Q

24

G

6

H

18

I

10

L

25

K

6

M

8

F

9

P

11

S

9

T

1

W

1

Y

19

V

Amino Acid Distribution

A: 12 R: 12 N: 12 D: 6 C: 1 E: 13 Q: 6 G: 24 H: 6 I: 18 L: 10 K: 25 M: 6 F: 8 P: 9 S: 11 T: 9 W: 1 Y: 1 V: 19

Length

209

Formula

C1011H1671N301O287S7

Mass

22859.65

PI

10.68

Net Charge

+19

Boman Index

64.03

Hydrophobicity

-0.406

Evidence 1 Activity

Source & Reference

Database Source NA