TPDB

3D PDB MODEL

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TPDB ID TPDB72171

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 326-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MSNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAKEAIKNANIEANDLDLIIVATLTPDNFMPSTACSVQKEIGAMNALCFDISAACSGFIYGLEIACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDGAGSAILSKTKEEGILEFHSGSNGLKGEHLTCGVLKANNTPNKNDSLEKNNFIKMNGKEIFRFAVGAMNETIYNIQEKTKWDLNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLLNKQDKIILVGFGGGLTFGGVAIVWSI

FASTA

>TPDB72171|Neurotoxin|length=326
MSNISVIGTGSYVPNNIITNDFLSTIVDTSDEWIRTRTGILERRISKGENTIYMATESAKEAIKNANIEANDLDLIIVATLTPDNFMPSTACSVQKEIGAMNALCFDISAACSGFIYGLEIACSMLKNSFRNKALIIGAENLSKIVDWEDRNTCVLFGDGAGSAILSKTKEEGILEFHSGSNGLKGEHLTCGVLKANNTPNKNDSLEKNNFIKMNGKEIFRFAVGAMNETIYNIQEKTKWDLNEVKYIISHQANSRIIEYTAKKLNTEKDKFYMNLDKYGNTSAASIPIALDEMNKRGLLNKQDKIILVGFGGGLTFGGVAIVWSI

Formula C1581H2528N424O491S15

Absent Amino Acids

Common Amino Acids I

Mass 35812.91

PI 5.69

Basic Residues 38

Acidic Residues 38

Hydrophobic Residues 133

Net Charge -3

Boman Index 62.32

Hydrophobicity -0.148

Aliphatic Index 92.21

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 34295

Absorbance 280nm 95.76

Polar Residues 94

number

25

A

9

R

31

N

16

D

6

C

22

E

4

Q

26

G

3

H

36

I

25

L

26

K

9

M

13

F

5

P

24

S

21

T

4

W

8

Y

13

V

Amino Acid Distribution

A: 25 R: 9 N: 31 D: 16 C: 6 E: 22 Q: 4 G: 26 H: 3 I: 36 L: 25 K: 26 M: 9 F: 13 P: 5 S: 24 T: 21 W: 4 Y: 8 V: 13

Length

326

Formula

C1581H2528N424O491S15

Mass

35812.91

PI

5.69

Net Charge

-3

Boman Index

62.32

Hydrophobicity

-0.148

Evidence 1 Activity

Source & Reference

Database Source NA