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Peptide record

TPDB72169

Neurotoxin standard
51 amino acids
Basic Information
3D PDB MODEL
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TPDB72169
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 51-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MANYIEVFSVLAIIFATVLAALAQDCSPEGAQCVRDSECCYNECIDSLCQP
Physicochemical Analysis
C237H371N59O78S7
HKW
A
5519.32
3.32
1
7
24
-6
6.53
0.559
97.65
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
60.79
18
Residue Composition
number
7
A
1
R
2
N
3
D
6
C
4
E
3
Q
1
G
0
H
4
I
4
L
0
K
1
M
2
F
2
P
4
S
1
T
0
W
2
Y
4
V
Amino Acid Distribution
A: 7 R: 1 N: 2 D: 3 C: 6 E: 4 Q: 3 G: 1 H: 0 I: 4 L: 4 K: 0 M: 1 F: 2 P: 2 S: 4 T: 1 W: 0 Y: 2 V: 4
Chemical Descriptors
51
C237H371N59O78S7
5519.32
3.32
-6
6.53
0.559
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Induces neurotoxic effect on honeybees, including slow movements, disorientation and paralysis (PubMed:29303983). Since it provokes similar symptoms than omega-atracotoxin, it is probable that it acts in the same way by inhibiting voltage-gated calcium channels. {ECO:0000269|PubMed:29303983, ECO:0000305}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Machimus arthriticus (Breck robberfly) (Asilus arthriticus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Induces neurotoxic effect on honeybees, including slow movements, disorientation and paralysis (PubMed:29303983). Since it provokes similar symptoms than omega-atracotoxin, it is probable that it acts in the same way by inhibiting voltage-gated calcium channels..
U-Asilidin(1)-Mar1a
insect
Asilidin-1 family
Evidence at protein level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. Is the most highly expressed peptide and is around 3000 times higher expressed in the thoracic glands compared to its body tissues. {ECO:0000305|PubMed:29303983}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Asilidin-1 family
U-Asilidin(1)-Mar1a
TISSUE SPECIFICITY: Expressed by the venom gland. Is the most highly expressed peptide and is around 3000 times higher expressed in the thoracic glands compared to its body tissues. {ECO:0000305|PubMed:29303983}.
insect