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Peptide record

TPDB72168

Neurotoxin standard
1207 amino acids
Basic Information
3D PDB MODEL
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TPDB72168
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 1207-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
GGCYQSCEPHTLKCGSVSFEAKCKSGWSCYPVTDNIASNACDRFKSCQDRWATVKETDAPCTSCVPGFQLTSRGYCSQDLNECNRNNGGCTNGKCINTEGSYHCDCDRGYLATSSRTKCEGVECEPLTLANGKVQSNKGSWIFGSRALFTCDDQARSVLDGPSYITCNLDAAGLTASWSGTSPTCQNDDEHDRFAEVFHLRFHGKKLDGVSLVTGLSPRSTAYRCHKDSTCQGIMTRAEEFEVSATGLTVYDGGVLTKTLGQSRADGDALTDDASMDIYTKVDVSSAAASSYQDVLDAMVGTSLGCYTTSSMASWEDYTLDDGRATTCNQICLQAGYDYFGIQASDKCWCGQKPPVEKVGDGECSTVCVNQANILCGSATTANIYQVYRDRSLGFCYTGNLGTETVPSAKTKDECVTVCRGQGYYTANIRNSGECFCDNSLPGGPRVDPTKCDEDGSGHSTVYMTNPAYFMSNDQGAQINPMTTRMYDDTGSVTGMTTGLFQRLPGLRIFTSDRLVLYSAEEVQFHDVQNDYADTCGEIKRIDGESDRSGDLILHFFHFRLSQLAKHTSDRASRVYIYAQKVVIDCDIQVQFSLMIRATKIVVSTGKVFKILVGSESSQIEMDVDDVKNNGPPRNLQQMKDSLQCARMLAQSWDDTEKQKLAFNILHEMTSPTAGNEAQRSVQTMASALKLQLEGMFKNDIHHVPSYSAAYFTYLMKADSDIVNAYAARLNALEVITTSRDDFLNYTQELEKIHQDTSIAQAKKRFDETMKLYKKEDLVYTKLQAAYDTALTNLRGVIPTFRKSIEAQEDHLRFKALLSFLELGVAAMDPAAVASVSKGFYDDVTDIAASSIWGIDQVVTNIDSFTDVMTNNLNEMMSEVKPYDGTKYAYEIEKVANMHVFVEEWRNFQVEVNNILGDDTVSALGGAGDYGRNLVKLTNIGMALTNAMINRAEKTRDAAQKRTTWDLLVEQGRRTTEVIKGFKAANSERAAANSVVAEQIRDITSEINGDLANFCEAYFFEKLEPCPKSTQPRFGGDLLSVQLSISRAEREAASLGLDGSPVSREVTITNTDASEDCIDVTQCPVTVFKRDRAFSYEVPIDNFDLSDWDKYRVKEIEVKAIGATPDRTETDLKLFVRSSGSFSGKSGGTHYNFLTDDFFCVYEYDINSPIDAPPESASGRCTVYARGSKKDMTRYATPYAAWMIEVD
Physicochemical Analysis
C5765H8990N1598O1883S72
S
133122.70
4.77
139
164
441
-43
265.23
-0.391
69.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
140270
105.37
392
Residue Composition
number
98
A
60
R
54
N
99
D
45
C
65
E
48
Q
84
G
18
H
52
I
79
L
61
K
27
M
46
F
35
P
100
S
97
T
12
W
48
Y
79
V
Amino Acid Distribution
A: 98 R: 60 N: 54 D: 99 C: 45 E: 65 Q: 48 G: 84 H: 18 I: 52 L: 79 K: 61 M: 27 F: 46 P: 35 S: 100 T: 97 W: 12 Y: 48 V: 79
Chemical Descriptors
1207
C5765H8990N1598O1883S72
133122.70
4.77
-43
265.23
-0.391
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent venom presynaptic neurotoxin that promotes a long-lasting increase in spontaneous neurotransmitter release at the peripheral and central synapses by selective activation of Cav2.2/CACNA1B (N-type) channels (PubMed:12485994). In addition, it drastically enhances synaptic-vesicle recycling, an effect that is prevented by the Cav2.2-specific inhibitor conotoxin-MVIIA (PubMed:20215402). It activates Cav2.2/CACNA1B by shifting the current-voltage relationship of channels towards more hyperpolarized potentiels in a reversible manner (PubMed:12485994). May have two separate sites of action on Cav2.2: one high affinity linked to changes in gating properties, and a second low affinity that results in block of current activity (PubMed:12485994). {ECO:0000269|PubMed:12485994, ECO:0000269|PubMed:20215402}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Glycera tridactyla (Glycerine worm) (Glycera convoluta)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Potent venom presynaptic neurotoxin that promotes a long-lasting increase in spontaneous neurotransmitter release at the peripheral and central synapses by selective activation of Cav2.2/CACNA1B (N-type) channels (PubMed:12485994). In addition, it drastically enhances synaptic-vesicle recycling, an effect that is prevented by the Cav2.2-specific inhibitor conotoxin-MVIIA (PubMed:20215402).
Glycerotoxin paralog 1 (GLTx paralog 1)
other
Evidence at protein level
Calcium Calcium channel impairing toxin Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Repeat Secreted Sushi Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed exclusively in the four pharyngeal lobes and in tissue located at the base of the teeth. No distinct expression is visible in the putative venom glands or elsewhere in the pharynx. {ECO:0000269|PubMed:28259138}.
Additional Detail Fields 6 fields
Calcium Calcium channel impairing toxin Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Repeat Secreted Sushi Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Glycerotoxin paralog 1 (GLTx paralog 1)
TISSUE SPECIFICITY: Expressed exclusively in the four pharyngeal lobes and in tissue located at the base of the teeth. No distinct expression is visible in the putative venom glands or elsewhere in the pharynx. {ECO:0000269|PubMed:28259138}.
other