Back to search

Peptide record

TPDB72157

Neurotoxin standard
57 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72157
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 57-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKTIIVLLLLTIVAAAVVESSPKARRQTECQIKNDCQRYCQSVKECKYGKCYCNYAG
Physicochemical Analysis
C278H462N78O82S7
HFW
CK
6433.62
8.82
9
4
23
+5
10.69
-0.068
88.95
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6335
98.47
22
Residue Composition
number
5
A
3
R
2
N
1
D
6
C
3
E
4
Q
2
G
0
H
4
I
4
L
6
K
1
M
0
F
1
P
3
S
3
T
0
W
4
Y
5
V
Amino Acid Distribution
A: 5 R: 3 N: 2 D: 1 C: 6 E: 3 Q: 4 G: 2 H: 0 I: 4 L: 4 K: 6 M: 1 F: 0 P: 1 S: 3 T: 3 W: 0 Y: 4 V: 5
Chemical Descriptors
57
C278H462N78O82S7
6433.62
8.82
+5
10.69
-0.068
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lychas mucronatus (Chinese swimming scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits voltage-gated potassium channels..
Potassium channel toxin alpha-KTx 17.2
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 17 subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at transcript level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 17 subfamily
Potassium channel toxin alpha-KTx 17.2
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion