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Peptide record

TPDB72150

Neurotoxin standard
86 amino acids
Basic Information
3D PDB MODEL
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TPDB72150
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 86-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MQLKIQLLMLVLMTVLTGVLGKDGYVVHEDTNCKYSCDVFKKWKYCSPLCQKKGAETGYCYSFACWCVGLPEETLVYGDKGTYCWE
Physicochemical Analysis
C444H678N104O125S11
R
L
9825.55
6.70
10
9
36
-0
6.57
0.028
79.19
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
27430
279.17
28
Residue Composition
number
2
A
0
R
1
N
4
D
8
C
5
E
3
Q
8
G
1
H
1
I
10
L
9
K
3
M
2
F
2
P
3
S
6
T
3
W
7
Y
8
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 4 C: 8 E: 5 Q: 3 G: 8 H: 1 I: 1 L: 10 K: 9 M: 3 F: 2 P: 2 S: 3 T: 6 W: 3 Y: 7 V: 8
Chemical Descriptors
86
C444H678N104O125S11
9825.55
6.70
-0
6.57
0.028
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds voltage-independently at site-3 of voltage-gated sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lychas mucronatus (Chinese swimming scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds voltage-independently at site-3 of voltage-gated sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission..
Neurotoxin LmNaTx35.2
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Neurotoxin LmNaTx35.2
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion