TPDB

3D PDB MODEL

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TPDB ID TPDB72148

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 311-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MIDLLIIAGPTAVGKTDISIKLAEKLNGEIISADSMQIYKYMDIGSAKITKDEMKGIPHHLIDVVEPHEEFNVSSFKALAEKSIKDIWNRGKLPIIAGGTGLYINSLIYNYDFTDADRDEKYREYLTKLAEDKGKEYVHSLLKDIDKESYEKLYPNDLKRVVRALEVYKITGKSISEYTKENEKKLYDIPYNVNYFILNMNREVLYERINKRVDIMMGKGLIEEVKKLESMGYTPDMQSMKGIGYKEVLFYLNGDISLDEAIYLIKKGSRNYAKRQLTWFRKDKRSIWIDKDKYRSEEEIVDKIIKMVKDK

FASTA

>TPDB72148|Neurotoxin|length=311
MIDLLIIAGPTAVGKTDISIKLAEKLNGEIISADSMQIYKYMDIGSAKITKDEMKGIPHHLIDVVEPHEEFNVSSFKALAEKSIKDIWNRGKLPIIAGGTGLYINSLIYNYDFTDADRDEKYREYLTKLAEDKGKEYVHSLLKDIDKESYEKLYPNDLKRVVRALEVYKITGKSISEYTKENEKKLYDIPYNVNYFILNMNREVLYERINKRVDIMMGKGLIEEVKKLESMGYTPDMQSMKGIGYKEVLFYLNGDISLDEAIYLIKKGSRNYAKRQLTWFRKDKRSIWIDKDKYRSEEEIVDKIIKMVKDK

Formula C1639H2615N419O483S11

Absent Amino Acids C

Common Amino Acids K

Mass 36270.97

PI 8.79

Basic Residues 58

Acidic Residues 52

Hydrophobic Residues 131

Net Charge +2

Boman Index 92.83

Hydrophobicity -0.525

Aliphatic Index 94.66

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 49280

Absorbance 280nm 135.87

Polar Residues 67

number

13

A

13

R

14

N

25

D

0

C

27

E

3

Q

18

G

4

H

35

I

26

L

41

K

11

M

6

F

7

P

18

S

10

T

3

W

22

Y

15

V

Amino Acid Distribution

A: 13 R: 13 N: 14 D: 25 C: 0 E: 27 Q: 3 G: 18 H: 4 I: 35 L: 26 K: 41 M: 11 F: 6 P: 7 S: 18 T: 10 W: 3 Y: 22 V: 15

Length

311

Formula

C1639H2615N419O483S11

Mass

36270.97

PI

8.79

Net Charge

+2

Boman Index

92.83

Hydrophobicity

-0.525

Evidence 1 Activity

Source & Reference

Database Source NA