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Peptide record

TPDB72144

Neurotoxin standard
84 amino acids
Basic Information
3D PDB MODEL
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TPDB72144
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 84-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKAIIFFIGCLMLIDLVAGSRSGYPVTQKGCVYSCFWGSNWWCNAECTALGGSSGYCAWPSCWCYSLPDNRNIWGSYPNNCGKK
Physicochemical Analysis
C418H609N107O114S11
H
G
9309.74
8.01
6
3
34
+3
-10.29
0.087
62.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
40950
439.86
32
Residue Composition
number
5
A
2
R
6
N
2
D
9
C
1
E
1
Q
10
G
0
H
5
I
5
L
4
K
2
M
3
F
4
P
9
S
2
T
6
W
5
Y
3
V
Amino Acid Distribution
A: 5 R: 2 N: 6 D: 2 C: 9 E: 1 Q: 1 G: 10 H: 0 I: 5 L: 5 K: 4 M: 2 F: 3 P: 4 S: 9 T: 2 W: 6 Y: 5 V: 3
Chemical Descriptors
84
C418H609N107O114S11
9309.74
8.01
+3
-10.29
0.087
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing..
Toxin To5 (PT-Arthr*-beta* NaTx2.7) (Toxin Tc66) (Toxin To66)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15025998, ECO:0000305|PubMed:22355312}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Toxin To5 (PT-Arthr*-beta* NaTx2.7) (Toxin Tc66) (Toxin To66)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15025998, ECO:0000305|PubMed:22355312}.
scorpion