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Peptide record

TPDB72143

Neurotoxin standard
69 amino acids
Basic Information
3D PDB MODEL
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TPDB72143
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 69-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MRFLNIFLFFAVMIAFVSASPVLEEEEIDIEPRITCDLIGNERLCVVHCLAKGFRGGWCDSRKVCNCRR
Physicochemical Analysis
C352H558N98O95S8
QY
R
7939.38
6.78
10
9
31
-0
11.14
0.355
98.84
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
74.00
13
Residue Composition
number
4
A
7
R
3
N
3
D
6
C
6
E
0
Q
4
G
1
H
6
I
6
L
2
K
2
M
6
F
2
P
3
S
1
T
1
W
0
Y
6
V
Amino Acid Distribution
A: 4 R: 7 N: 3 D: 3 C: 6 E: 6 Q: 0 G: 4 H: 1 I: 6 L: 6 K: 2 M: 2 F: 6 P: 2 S: 3 T: 1 W: 1 Y: 0 V: 6
Chemical Descriptors
69
C352H558N98O95S8
7939.38
6.78
-0
11.14
0.355
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: The recombinant peptide moderately increases Kv11.1/KCNH2/ERG1 currents and shifts the voltage-dependence of the channel activation to hyperpolarised potentials (PubMed:31870846). In vivo, induces neurotoxic effects when injected into insects (tested on L.cuprina and A.domesticus) (PubMed:31870846). {ECO:0000269|PubMed:31870846}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Dolopus genitalis (Giant Australian assassin fly) (Asilus genitalis)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
The recombinant peptide moderately increases Kv11.1/KCNH2/ERG1 currents and shifts the voltage-dependence of the channel activation to hyperpolarised potentials (PubMed:31870846). In vivo, induces neurotoxic effects when injected into insects (tested on L.cuprina and A.domesticus) (PubMed:31870846)..
U-Asilidin(12)-Dg3b
insect
Asilidin-12 family
Evidence at protein level
3D-structure Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30400621, ECO:0000305|PubMed:31870846}.
Additional Detail Fields 7 fields
3D-structure Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Asilidin-12 family
U-Asilidin(12)-Dg3b
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30400621, ECO:0000305|PubMed:31870846}.
insect