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Peptide record

TPDB72142

Neurotoxin standard
74 amino acids
Basic Information
3D PDB MODEL
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TPDB72142
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 74-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MLVFYALLFVTVFSNTVMGATIDKPIPKPILREAIEEIEVNKRAQNHYCKEHNCPPGKHCPKVPIACVYGPCCF
Physicochemical Analysis
C378H591N97O99S8
W
P
8334.92
8.02
11
6
31
+2
14.51
0.126
86.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
58.13
18
Residue Composition
number
5
A
2
R
4
N
1
D
6
C
5
E
1
Q
3
G
3
H
6
I
4
L
6
K
2
M
4
F
8
P
1
S
3
T
0
W
3
Y
7
V
Amino Acid Distribution
A: 5 R: 2 N: 4 D: 1 C: 6 E: 5 Q: 1 G: 3 H: 3 I: 6 L: 4 K: 6 M: 2 F: 4 P: 8 S: 1 T: 3 W: 0 Y: 3 V: 7
Chemical Descriptors
74
C378H591N97O99S8
8334.92
8.02
+2
14.51
0.126
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin that inhibits voltage-gated potassium channel currents in DRG neurons (IC(50)=about 570 nM). In vivo, induces neurotoxicity shown by twitching, paralysis, and body contraction. In vivo, insects injected with this toxin showed signs of neurotoxicity including twitching, paralysis, and body contraction. {ECO:0000269|PubMed:22595790}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Toxin that inhibits voltage-gated potassium channel currents in DRG neurons (IC(50)=about 570 nM). In vivo, induces neurotoxicity shown by twitching, paralysis, and body contraction.
Kappa-scoloptoxin(07)-Ssm2a (Kappa-SLPTX(07)-Ssm2a) (Kappa-scoloptoxin-Ssm2a) (Kappa-SLPTX-Ssm2a)
other
Scoloptoxin-07 family
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Scoloptoxin-07 family
Kappa-scoloptoxin(07)-Ssm2a (Kappa-SLPTX(07)-Ssm2a) (Kappa-scoloptoxin-Ssm2a) (Kappa-SLPTX-Ssm2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
other