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Peptide record

TPDB72140

Neurotoxin standard
96 amino acids
Basic Information
3D PDB MODEL
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TPDB72140
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 96-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKLILLIAIFSALAVVNLGTPSADQVRYNYTELPNGEYCYTPRRRCTSADQCCRPYDTTAAFHGCGRIWPKDKREKVDRCYICNNEKTLCTSVMGK
Physicochemical Analysis
C474H754N136O140S10
RCT
10918.63
8.49
15
9
35
+5
16.37
-0.354
71.15
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14940
136.83
33
Residue Composition
number
7
A
8
R
5
N
5
D
8
C
4
E
2
Q
5
G
1
H
5
I
7
L
6
K
2
M
2
F
5
P
4
S
8
T
1
W
6
Y
5
V
Amino Acid Distribution
A: 7 R: 8 N: 5 D: 5 C: 8 E: 4 Q: 2 G: 5 H: 1 I: 5 L: 7 K: 6 M: 2 F: 2 P: 5 S: 4 T: 8 W: 1 Y: 6 V: 5
Chemical Descriptors
96
C474H754N136O140S10
10918.63
8.49
+5
16.37
-0.354
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Moderate insecticidal toxin with probable ion channel impairing activity. In vivo, induces irreversible paralysis in sheep blowflies (L.cuprina), leading to death at moderate doses (9.7 nmol/g). {ECO:0000269|PubMed:32398368}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Neurotoxin Ion channel impairing toxin
Moderate insecticidal toxin with probable ion channel impairing activity. In vivo, induces irreversible paralysis in sheep blowflies (L.cuprina), leading to death at moderate doses (9.7 nmol/g)..
U4-hexatoxin-Hi1a (U4-HXTX-Hi1a) (SF6 peptide)
spider
Neurotoxin 27 (Jztx-72) family, ICK-72 subfamily
Evidence at protein level
3D-structure Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368}.
Additional Detail Fields 7 fields
3D-structure Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Neurotoxin 27 (Jztx-72) family, ICK-72 subfamily
U4-hexatoxin-Hi1a (U4-HXTX-Hi1a) (SF6 peptide)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368}.
spider