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Peptide record

TPDB72136

Neurotoxin standard
58 amino acids
Basic Information
3D PDB MODEL
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TPDB72136
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 58-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
KKTSRLFTLVLIVLAMNVMMAIISDPVVEAVGCEECPMHCKGKMAKPTCYDGVCNCNV
Physicochemical Analysis
C271H453N71O78S11
QW
V
6306.67
7.63
7
5
26
+1
10.61
0.528
93.97
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1865
29.57
15
Residue Composition
number
4
A
1
R
3
N
2
D
6
C
3
E
0
Q
3
G
1
H
3
I
4
L
5
K
5
M
1
F
3
P
2
S
3
T
0
W
1
Y
8
V
Amino Acid Distribution
A: 4 R: 1 N: 3 D: 2 C: 6 E: 3 Q: 0 G: 3 H: 1 I: 3 L: 4 K: 5 M: 5 F: 1 P: 3 S: 2 T: 3 W: 0 Y: 1 V: 8
Chemical Descriptors
58
C271H453N71O78S11
6306.67
7.63
+1
10.61
0.528
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potassium channel inhibitor. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus israelis (Israeli scorpion) (Buthus occitanus israelis)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Potassium channel inhibitor..
Potassium channel toxin alpha-KTx 9.9 (Toxin Tx549)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 09 subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at transcript level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 09 subfamily
Potassium channel toxin alpha-KTx 9.9 (Toxin Tx549)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
scorpion