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Peptide record

TPDB72134

Neurotoxin standard
242 amino acids
Basic Information
3D PDB MODEL
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TPDB72134
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 242-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MILLSLYLCLAAMLHQSEGEASPKLPGLMTSNPDQQTEITDKHNNLRRIVEPTASNMLKMTWSNKIAQNAQRSANQCTLEHTSKEERTIDGVECGENLFFSSAPYTWSYAIQNWFDERKYFRFNYGPTAQNVMIGHYTQVVWYRSYELGCAIAYCPDQPTYKYYQVCQYCPGGNIRSRKYTPYSIGPPCGDCPDACDNGLCTNPCKQNDVYNNCPDLKKQVGCGHPIMKDCMATCKCLTEIK
Physicochemical Analysis
C1198H1838N328O366S25
NC
27493.25
6.89
28
23
83
-0
41.87
-0.549
60.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
46840
170.37
94
Residue Composition
number
14
A
9
R
17
N
11
D
17
C
12
E
14
Q
14
G
5
H
12
I
16
L
14
K
8
M
5
F
16
P
14
S
16
T
4
W
16
Y
8
V
Amino Acid Distribution
A: 14 R: 9 N: 17 D: 11 C: 17 E: 12 Q: 14 G: 14 H: 5 I: 12 L: 16 K: 14 M: 8 F: 5 P: 16 S: 14 T: 16 W: 4 Y: 16 V: 8
Chemical Descriptors
242
C1198H1838N328O366S25
27493.25
6.89
-0
41.87
-0.549
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alters a variety of ion channel activities, including voltage-gated potassium channels (Kv) (PubMed:8071987), voltage-gated calcium channels (L-, N-, and P-type) (Cav) (PubMed:8817251) and ryanodine receptors (RyR) (PubMed:7647234). Is toxic to mice (causes lethargy, partial paralysis of rear limbs and lowering of body temperature). {ECO:0000269|PubMed:7647234, ECO:0000269|PubMed:8071987, ECO:0000269|PubMed:8817251}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav) ryanodine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heloderma horridum horridum (Mexican beaded lizard)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Alters a variety of ion channel activities, including voltage-gated potassium channels (Kv) (PubMed:8071987), voltage-gated calcium channels (L-, N-, and P-type) (Cav) (PubMed:8817251) and ryanodine receptors (RyR) (PubMed:7647234). Is toxic to mice (causes lethargy, partial paralysis of rear limbs and lowering of body temperature)..
Cysteine-rich venom protein helothermine (CRVP HLTx)
other
CRISP family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
CRISP family
Cysteine-rich venom protein helothermine (CRVP HLTx)
TISSUE SPECIFICITY: Expressed by the venom gland.
other