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Peptide record

TPDB72131

Neurotoxin standard
1214 amino acids
Basic Information
3D PDB MODEL
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TPDB72131
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 1214-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MHSKELQTISAAVARKAVPNTMVIRLKRDEEDGEMTLEERQAQCKAIEYSNSVFGMIADVANDIGSIPVIGEVVGIVTAPIAIVSHITSAGLDIASTALDCDDIPFDEIKEILEERFNEIDRKLDKNTAALEEVSKLVSKTFVTVEKTRNEMNENFKLVLETIESKEIKSIVFKINDFKKFFEKERQRIKGLPKDRYVAKLLEQKGILGSLKEVREPSGNSLSSALNELLDKNNNYAIPKVVDDNKAFQALYALFYGTQTYAAVMFFLLEQHSYLADYYYQKGDDVNFNAEFNNVAIIFDDFKSSLTGGDDGLIDNVIEVLNTVKALPFIKNADSKLYRELVTRTKALETLKNQIKTTDLPLIDDIPETLSQVNFPNDENQLPTPIGNWVDGVEVRYAVQYESKGMYSKFSEWSEPFTVQGNACPTIKVRVDPKKRNRLIFRKFNSGKPQFAGTMTHSQTNFKDIHRDLYDAALNINKLKAVDEATTLIEKGADIEAKFDNDRSAMHAVAYRGNNKIALRFLLKNQSIDIELKDKNGFTPLHIAAEAGQAGFVKLLINHGADVNAKTSKTNLTPLHLATRSGFSKTVRNLLESPNIKVNEKEDDGFTPLHTAVMSTYMVVDALLNHPDIDKNAQSTSGLTPFHLAIINESQEVAESLVESNADLNIQDVNHMAPIHFAASMGSIKMLRYLISIKDKVSINSVTENNNWTPLHFAIYFKKEDAAKELLKQDDINLTIVADGNLTVLHLAVSTGQINIIKELLKRGSNIEEKTGEGYTSLHIAAMRKEPEIAVVLIENGADIEARSADNLTPLHSAAKIGRKSTVLYLLEKGADIGAKTADGSTALHLAVSGRKMKTVETLLNKGANLKEYDNNKYLPIHKAIINDDLDMVRLFLEKDPSLKDDETEEGRTSIMLIVQKLLLELYNYFINNYAETLDEEALFNRLDEQGKLELAYIFHNKEGDAKEAVKPTILVTIKLMEYCLKKLREESGAPEGSFDSPSSKQCISTFSEDEMFRRTLPEIVKETNSRYLPLKGFSRSLNKFLPSLKFAESKNSYRSENFVSNIDSNGALLLLDVFIRKFTNEKYNLTGKEAVPYLEAKASSLRIASKFEELLTEVKGIPAGELINMAEVSSNIHKAIASGKPVSKVLCSYLDTFSELNSQQMEELVNTYLSTKPSVITSASADYQKLPNLLTATCLEPERMAQLIDVHQKMFLR
Physicochemical Analysis
C6050H9681N1611O1865S31
L
135821.95
5.48
171
173
499
-23
330.18
-0.303
94.66
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
69025
50.82
311
Residue Composition
number
98
A
43
R
83
N
74
D
7
C
99
E
31
Q
54
G
23
H
86
I
130
L
105
K
24
M
51
F
41
P
85
S
70
T
3
W
35
Y
72
V
Amino Acid Distribution
A: 98 R: 43 N: 83 D: 74 C: 7 E: 99 Q: 31 G: 54 H: 23 I: 86 L: 130 K: 105 M: 24 F: 51 P: 41 S: 85 T: 70 W: 3 Y: 35 V: 72
Chemical Descriptors
1214
C6050H9681N1611O1865S31
135821.95
5.48
-23
330.18
-0.303
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal presynaptic neurotoxin that induces massive neurotransmitter release at insect (but not vertebrate) neuromuscular junctions. Native toxin forms cation-permeable pores (with high permeability to calcium) in lipid membranes locust muscle membrane and artificial lipid bilayers (PubMed:34845192, PubMed:8631785). May bind to insect neurexin-1 homolog, insect adhesion G protein-coupled receptor L1 homolog, and insect receptor-type tyrosine-protein phosphatase S homolog, and induces neurotransmitter exocytosis both by forming tetrameric pores in membranes and signaling via G protein-coupled receptor (By similarity). Oligomerization is a process independent of divalent cations (PubMed:34845192). {ECO:0000250|UniProtKB:P23631, ECO:0000269|PubMed:34845192, ECO:0000269|PubMed:8631785}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)
Neurotoxin Presynaptic neurotoxin
Insecticidal presynaptic neurotoxin that induces massive neurotransmitter release at insect (but not vertebrate) neuromuscular junctions. Native toxin forms cation-permeable pores (with high permeability to calcium) in lipid membranes locust muscle membrane and artificial lipid bilayers (PubMed:34845192, PubMed:8631785).
Delta-latroinsectotoxin-Lt1a (Delta-LIT-Lt1a) (Delta-latroinsectotoxin) (Delta-LIT)
spider
Cationic peptide 01 (latrotoxin) family, 04 (delta-latroinsectotoxin) subfamily
Evidence at protein level
3D-structure ANK repeat Cleavage on pair of basic residues Direct protein sequencing Exocytosis Membrane Neurotoxin Presynaptic neurotoxin Repeat Secreted Signal Target cell membrane Target membrane Toxin Transmembrane
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8631785}.
Additional Detail Fields 7 fields
3D-structure ANK repeat Cleavage on pair of basic residues Direct protein sequencing Exocytosis Membrane Neurotoxin Presynaptic neurotoxin Repeat Secreted Signal Target cell membrane Target membrane Toxin Transmembrane
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Cationic peptide 01 (latrotoxin) family, 04 (delta-latroinsectotoxin) subfamily
Delta-latroinsectotoxin-Lt1a (Delta-LIT-Lt1a) (Delta-latroinsectotoxin) (Delta-LIT)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8631785}.
spider