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Peptide record

TPDB72123

Neurotoxin standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB72123
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 83-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MRNTTFLVLNVMLLVSVALFCAADPEMEKSSFAEILDTGNPEQERKCLAEAADCSPWSGDSCCKPYLCSCIFFYPCSCRPKGW
Physicochemical Analysis
C405H622N102O121S12
H
C
9240.72
4.48
7
10
33
-3
9.37
0.111
69.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14480
156.70
26
Residue Composition
number
7
A
3
R
3
N
4
D
9
C
6
E
1
Q
3
G
0
H
2
I
8
L
4
K
3
M
5
F
6
P
8
S
3
T
2
W
2
Y
4
V
Amino Acid Distribution
A: 7 R: 3 N: 3 D: 4 C: 9 E: 6 Q: 1 G: 3 H: 0 I: 2 L: 8 K: 4 M: 3 F: 5 P: 6 S: 8 T: 3 W: 2 Y: 2 V: 4
Chemical Descriptors
83
C405H622N102O121S12
9240.72
4.48
-3
9.37
0.111
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits sodium channels (Nav) of insects. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits sodium channels (Nav) of insects..
U2-hexatoxin-Hi1a (U2-HXTX-Hi1a) (SF3 peptide) (Toxin AcTx-Hi:OB4219)
spider
Neurotoxin 07 (Beta/delta-agtx) family
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11876637, ECO:0000305|PubMed:32398368}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family
U2-hexatoxin-Hi1a (U2-HXTX-Hi1a) (SF3 peptide) (Toxin AcTx-Hi:OB4219)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11876637, ECO:0000305|PubMed:32398368}.
spider