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Peptide record

TPDB72121

Neurotoxin standard
62 amino acids
Basic Information
3D PDB MODEL
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TPDB72121
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 62-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MEGIAKITLILLFLFVTMHTFANWNTEAAVCVYRTCDKDCKRRGYRSGKCINNACKCYPYGK
Physicochemical Analysis
C316H497N87O85S8
Q
CK
7131.43
9.11
11
4
26
+6
4.62
-0.068
72.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11835
165.96
20
Residue Composition
number
5
A
4
R
4
N
2
D
6
C
2
E
0
Q
4
G
1
H
4
I
4
L
6
K
2
M
3
F
1
P
1
S
5
T
1
W
4
Y
3
V
Amino Acid Distribution
A: 5 R: 4 N: 4 D: 2 C: 6 E: 2 Q: 0 G: 4 H: 1 I: 4 L: 4 K: 6 M: 2 F: 3 P: 1 S: 1 T: 5 W: 1 Y: 4 V: 3
Chemical Descriptors
62
C316H497N87O85S8
7131.43
9.11
+6
4.62
-0.068
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Shaker B (Sh) and voltage-gated potassium-channels Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3. Also inhibits small conductance calcium-activated potassium channels (KCNN) and intermediate conductance calcium-activated potassium channel (KCa3.1/KCNN4). {ECO:0000269|PubMed:14498829, ECO:0000269|PubMed:9688256}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides noxius (Mexican scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Shaker B (Sh) and voltage-gated potassium-channels Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3. Also inhibits small conductance calcium-activated potassium channels (KCNN) and intermediate conductance calcium-activated potassium channel (KCa3.1/KCNN4)..
Potassium channel toxin alpha-KTx 10.1 (Cobatoxin-1) (CoTx1) (gtIX)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Evidence at protein level
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:14498829, ECO:0000305|PubMed:9688256}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Potassium channel toxin alpha-KTx 10.1 (Cobatoxin-1) (CoTx1) (gtIX)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:14498829, ECO:0000305|PubMed:9688256}.
scorpion