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Peptide record

TPDB72116

Neurotoxin standard
151 amino acids
Basic Information
3D PDB MODEL
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TPDB72116
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 151-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
LVIETIENIATKLSISISFKTDVTQTLIDITEIDLNAQDKILIRNTNAVINIKSKVGLTPLHLATLQNNLSVSKGAYLNDGDANGMTPLHYAAMTGNLEMVDFLKWTPLHLAILFKQLVIELLAKTFFDLAIENGRLNIVAFAVEKYIAAR
Physicochemical Analysis
C759H1235N193O220S3
C
L
16680.50
5.85
16
15
76
-2
18.91
0.337
127.95
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
9970
59.77
38
Residue Composition
number
15
A
3
R
12
N
8
D
0
C
7
E
4
Q
6
G
3
H
17
I
22
L
10
K
3
M
6
F
3
P
6
S
13
T
1
W
3
Y
9
V
Amino Acid Distribution
A: 15 R: 3 N: 12 D: 8 C: 0 E: 7 Q: 4 G: 6 H: 3 I: 17 L: 22 K: 10 M: 3 F: 6 P: 3 S: 6 T: 13 W: 1 Y: 3 V: 9
Chemical Descriptors
151
C759H1235N193O220S3
16680.50
5.85
-2
18.91
0.337
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal presynaptic neurotoxin that induces massive neurotransmitter release at insect (but not vertebrate) neuromuscular junctions. Native toxin forms cation-permeable pores (with high permeability to calcium) in lipid membranes locust muscle membrane and artificial lipid bilayers (By similarity). May bind to insect neurexin-1 homolog, insect adhesion G protein-coupled receptor L1 homolog, and insect receptor-type tyrosine-protein phosphatase S homolog, and induces neurotransmitter exocytosis both by forming tetrameric pores in membranes and signaling via G protein-coupled receptor (By similarity). Oligomerization is a process independent of divalent cations (By similarity). The toxin forms channels with 0.55-0.58 nm entrance diameter and a relatively small conductance in planar phospholipid membranes (By similarity). {ECO:0000250|UniProtKB:P23631, ECO:0000250|UniProtKB:Q02989, ECO:0000250|UniProtKB:Q25338}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Latrodectus hasselti (Redback spider)
Neurotoxin Presynaptic neurotoxin
Insecticidal presynaptic neurotoxin that induces massive neurotransmitter release at insect (but not vertebrate) neuromuscular junctions. Native toxin forms cation-permeable pores (with high permeability to calcium) in lipid membranes locust muscle membrane and artificial lipid bilayers (By similarity).
Alpha-latroinsectotoxin-Lh1a (Alpha-LIT-Lh1a) (Alpha-latroinsectotoxin) (Alpha-LIT)
spider
Cationic peptide 01 (latrotoxin) family, 02 (alpha-latroinsectotoxin) subfamily
Evidence at protein level
ANK repeat Cleavage on pair of basic residues Direct protein sequencing Exocytosis Membrane Neurotoxin Presynaptic neurotoxin Repeat Secreted Target cell membrane Target membrane Toxin Transmembrane
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22001442}.
Additional Detail Fields 7 fields
ANK repeat Cleavage on pair of basic residues Direct protein sequencing Exocytosis Membrane Neurotoxin Presynaptic neurotoxin Repeat Secreted Target cell membrane Target membrane Toxin Transmembrane
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Cationic peptide 01 (latrotoxin) family, 02 (alpha-latroinsectotoxin) subfamily
Alpha-latroinsectotoxin-Lh1a (Alpha-LIT-Lh1a) (Alpha-latroinsectotoxin) (Alpha-LIT)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22001442}.
spider