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Peptide record

TPDB72110

Neurotoxin standard
86 amino acids
Basic Information
3D PDB MODEL
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TPDB72110
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 86-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKTVILVVIALMVIEVQGDGYLMVRAGIEKGCKIWCVINNDYCNRDCKLKGGTYGYCYFWKLACYCEGLPESSPDIWTYEKNTCSP
Physicochemical Analysis
C438H675N107O124S11
H
CG
9776.48
6.24
9
9
37
-0
6.79
0.085
86.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
27430
280.57
27
Residue Composition
number
3
A
2
R
4
N
4
D
8
C
5
E
1
Q
8
G
0
H
7
I
6
L
7
K
3
M
1
F
3
P
3
S
4
T
3
W
7
Y
7
V
Amino Acid Distribution
A: 3 R: 2 N: 4 D: 4 C: 8 E: 5 Q: 1 G: 8 H: 0 I: 7 L: 6 K: 7 M: 3 F: 1 P: 3 S: 3 T: 4 W: 3 Y: 7 V: 7
Chemical Descriptors
86
C438H675N107O124S11
9776.48
6.24
-0
6.79
0.085
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lychas mucronatus (Chinese swimming scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing..
Neurotoxin LmNaTx34.1
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Neurotoxin LmNaTx34.1
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion