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Peptide record

TPDB72109

Neurotoxin standard
63 amino acids
Basic Information
3D PDB MODEL
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TPDB72109
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 63-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSPYSILFVVVIALCLLPESIVGVCWDTGCQLNAWAVRGCAQYGMRDVNMKSCSGGIIYTCCD
Physicochemical Analysis
C299H470N76O86S10
H
CV
6826.08
4.45
3
4
30
-1
-2.35
0.738
100.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
15845
232.12
21
Residue Composition
number
4
A
2
R
2
N
3
D
7
C
1
E
2
Q
6
G
0
H
5
I
5
L
1
K
3
M
1
F
2
P
5
S
2
T
2
W
3
Y
7
V
Amino Acid Distribution
A: 4 R: 2 N: 2 D: 3 C: 7 E: 1 Q: 2 G: 6 H: 0 I: 5 L: 5 K: 1 M: 3 F: 1 P: 2 S: 5 T: 2 W: 2 Y: 3 V: 7
Chemical Descriptors
63
C299H470N76O86S10
6826.08
4.45
-1
-2.35
0.738
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin with insecticidal activity. High doses of recombinant toxin causes impaired motor behavior of D.melanogaster, which progress slowly to paralysis and death after several hours. {ECO:0000269|PubMed:38889720}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pristhesancus plagipennis (Common assassin bug)
Neurotoxin
Toxin with insecticidal activity. High doses of recombinant toxin causes impaired motor behavior of D.melanogaster, which progress slowly to paralysis and death after several hours..
Venom peptide U-reduvitoxin-Pp19 (U-RDTX-Pp19) (Trans-defensin) (Venom peptide Pp19a)
insect
Evidence at protein level
3D-structure Disulfide bond Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Hemolymph (at protein level) (PubMed:38889720). Also weakly expressed by the venom gland (at protein level) (PubMed:29472578, PubMed:38889720). {ECO:0000269|PubMed:29472578, ECO:0000269|PubMed:38889720}.
Additional Detail Fields 6 fields
3D-structure Disulfide bond Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at protein level
Venom peptide U-reduvitoxin-Pp19 (U-RDTX-Pp19) (Trans-defensin) (Venom peptide Pp19a)
TISSUE SPECIFICITY: Hemolymph (at protein level) (PubMed:38889720). Also weakly expressed by the venom gland (at protein level) (PubMed:29472578, PubMed:38889720). {ECO:0000269|PubMed:29472578, ECO:0000269|PubMed:38889720}.
insect