TPDB

3D PDB MODEL

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TPDB ID TPDB72100

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 222-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MSPSAGLQFSLYFLQTKKVLWKLTDKEKGLCYILLFTLCFFADQENGGKALASPPGIWKRADVTFDSNTAFSSLVVSANKKTVKNVGVPQVVPDNPERFNSSPCVLGSPGFRSGKHYFEVKYGTQREWAVGIAGKSVKRKGNLMLVPEERIWQMGLWWLRHLETDPGRVHSTSGKITVFVDYNGGNVIFDLNRINTTLKANFNGEEVVPFFYLGGTVSLTTL

FASTA

>TPDB72100|Neurotoxin|length=222
MSPSAGLQFSLYFLQTKKVLWKLTDKEKGLCYILLFTLCFFADQENGGKALASPPGIWKRADVTFDSNTAFSSLVVSANKKTVKNVGVPQVVPDNPERFNSSPCVLGSPGFRSGKHYFEVKYGTQREWAVGIAGKSVKRKGNLMLVPEERIWQMGLWWLRHLETDPGRVHSTSGKITVFVDYNGGNVIFDLNRINTTLKANFNGEEVVPFFYLGGTVSLTTL

Formula C1131H1745N297O315S6

Absent Amino Acids

Common Amino Acids L

Mass 24735.46

PI 9.76

Basic Residues 29

Acidic Residues 18

Hydrophobic Residues 90

Net Charge +8

Boman Index 25.50

Hydrophobicity -0.144

Aliphatic Index 82.88

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 42065

Absorbance 280nm 170.06

Polar Residues 59

number

10

A

9

R

13

N

8

D

3

C

10

E

6

Q

21

G

3

H

7

I

22

L

17

K

3

M

15

F

11

P

16

S

15

T

6

W

6

Y

21

V

Amino Acid Distribution

A: 10 R: 9 N: 13 D: 8 C: 3 E: 10 Q: 6 G: 21 H: 3 I: 7 L: 22 K: 17 M: 3 F: 15 P: 11 S: 16 T: 15 W: 6 Y: 6 V: 21

Length

222

Formula

C1131H1745N297O315S6

Mass

24735.46

PI

9.76

Net Charge

+8

Boman Index

25.50

Hydrophobicity

-0.144

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. {ECO:0000250|UniProtKB:P83234}.

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Crotalus adamanteus (Eastern diamondback rattlesnake)

Neurotoxin Type Neurotoxin

Mechanism

Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal..

Protein Name Vespryn

Venom Taxon Group snake

Protein Family Ohanin/vespryn family

Protein Existence Evidence at protein level

Keywords Glycoprotein Neurotoxin Secreted Signal Toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24231107}.

Keywords

Glycoprotein Neurotoxin Secreted Signal Toxin

Neurotoxin_Type

Neurotoxin

Protein_Existence

Evidence at protein level

Protein_Family

Ohanin/vespryn family

Protein_Name

Vespryn

Tissue_Specificity

TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24231107}.

Venom_Taxon_Group

snake