TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB72096

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 317-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MKLGFLIPNHPNEKRVALLPEHVKGFNNELVIETGFGETLGISDAEYVKVGCTIASREEIFKTCEGIFSLKVLKPQDYKHIREGQIIVGWTHPEGSGKIFMEEQGIPKNLIIVDLDNIHPSIYYKDYVIPMEWIPSNFVRKNSYIAGYASTMHAVMNYGSIPTSETKVAILGSGNVSQGAFSAISKFNPDIRMFYRKTMNQLKDELEEFDIIINGIEMDNPNKHILTLEDQMRLKKNCLIIDAAANLGKAIEGARHTTASDPIYNKDGKYYYAVNNSPSIFYRQSSKAISEAFSKHVYSKELEFYLDVIAEVEEMIV

FASTA

>TPDB72096|Neurotoxin|length=317
MKLGFLIPNHPNEKRVALLPEHVKGFNNELVIETGFGETLGISDAEYVKVGCTIASREEIFKTCEGIFSLKVLKPQDYKHIREGQIIVGWTHPEGSGKIFMEEQGIPKNLIIVDLDNIHPSIYYKDYVIPMEWIPSNFVRKNSYIAGYASTMHAVMNYGSIPTSETKVAILGSGNVSQGAFSAISKFNPDIRMFYRKTMNQLKDELEEFDIIINGIEMDNPNKHILTLEDQMRLKKNCLIIDAAANLGKAIEGARHTTASDPIYNKDGKYYYAVNNSPSIFYRQSSKAISEAFSKHVYSKELEFYLDVIAEVEEMIV

Formula C1618H2520N416O477S13

Absent Amino Acids

Common Amino Acids I

Mass 35849.09

PI 5.72

Basic Residues 43

Acidic Residues 41

Hydrophobic Residues 134

Net Charge -6

Boman Index 74.35

Hydrophobicity -0.237

Aliphatic Index 90.13

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 34965

Absorbance 280nm 97.53

Polar Residues 80

number

19

A

9

R

20

N

14

D

3

C

27

E

7

Q

21

G

9

H

35

I

20

L

25

K

10

M

14

F

14

P

22

S

12

T

2

W

16

Y

18

V

Amino Acid Distribution

A: 19 R: 9 N: 20 D: 14 C: 3 E: 27 Q: 7 G: 21 H: 9 I: 35 L: 20 K: 25 M: 10 F: 14 P: 14 S: 22 T: 12 W: 2 Y: 16 V: 18

Length

317

Formula

C1618H2520N416O477S13

Mass

35849.09

PI

5.72

Net Charge

-6

Boman Index

74.35

Hydrophobicity

-0.237

Evidence 1 Activity

Source & Reference

Database Source NA