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Peptide record

TPDB72090

Neurotoxin standard
58 amino acids
Basic Information
3D PDB MODEL
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TPDB72090
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 58-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
LAMAMGDAVADAQARAMAAAYAIAGKEKEKLKQCFKDMTLAAIDYAKHKVEKHLFKCI
Physicochemical Analysis
C280H458N76O78S6
NPSW
A
6329.54
9.33
12
7
32
+3
12.82
0.012
82.93
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
3105
49.06
7
Residue Composition
number
15
A
1
R
0
N
4
D
2
C
3
E
2
Q
2
G
2
H
3
I
4
L
9
K
4
M
2
F
0
P
0
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 15 R: 1 N: 0 D: 4 C: 2 E: 3 Q: 2 G: 2 H: 2 I: 3 L: 4 K: 9 M: 4 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
58
C280H458N76O78S6
6329.54
9.33
+3
12.82
0.012
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin that causes irreversible rapid flaccid paralysis in blowflies and honeybees upon intrathoracic injection (PubMed:37888631). Causes a quick and irreversible cytolytic effect (at 10 uM) indicating it possibly acts as a pore-forming peptide (PubMed:38786948). Shows only weak effect on aphids (A.pisum) at high doses 24 hours post intrathoracic injection (PubMed:37888631). In vitro, is not cytotoxic on the dipteran S2 Drosophila embryonic cell line (PubMed:37888631). {ECO:0000269|PubMed:37888631, ECO:0000269|PubMed:38786948}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tetramorium bicarinatum (Tramp ant)
Neurotoxin
Neurotoxin that causes irreversible rapid flaccid paralysis in blowflies and honeybees upon intrathoracic injection (PubMed:37888631). Causes a quick and irreversible cytolytic effect (at 10 uM) indicating it possibly acts as a pore-forming peptide (PubMed:38786948).
U11-myrmicitoxin-Tb1a (U11-MYRTX-Tb1a)
insect
Formicidae venom precursor-01 superfamily
Evidence at protein level
3D-structure Cytolysis Direct protein sequencing Disulfide bond Ion transport Membrane Neurotoxin Secreted Target cell membrane Target membrane Toxin Transmembrane Transport
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30149710}.
Additional Detail Fields 7 fields
3D-structure Cytolysis Direct protein sequencing Disulfide bond Ion transport Membrane Neurotoxin Secreted Target cell membrane Target membrane Toxin Transmembrane Transport
Neurotoxin
Evidence at protein level
Formicidae venom precursor-01 superfamily
U11-myrmicitoxin-Tb1a (U11-MYRTX-Tb1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30149710}.
insect