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Peptide record

TPDB72085

Neurotoxin standard
65 amino acids
Basic Information
3D PDB MODEL
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TPDB72085
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 65-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKMKIFIITIVIALFITSIVEAQNKLDVKCVRLETCREPCKKQLCLLPMKCMNGKCVCSPSRKIC
Physicochemical Analysis
C324H563N87O84S12
HWY
K
7406.29
9.28
12
4
27
+8
11.87
0.466
109.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
500
6.75
18
Residue Composition
number
2
A
3
R
2
N
1
D
8
C
3
E
2
Q
1
G
0
H
8
I
6
L
9
K
4
M
2
F
3
P
3
S
3
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 1 C: 8 E: 3 Q: 2 G: 1 H: 0 I: 8 L: 6 K: 9 M: 4 F: 2 P: 3 S: 3 T: 3 W: 0 Y: 0 V: 5
Chemical Descriptors
65
C324H563N87O84S12
7406.29
9.28
+8
11.87
0.466
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lychas mucronatus (Chinese swimming scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits voltage-gated potassium channels..
Potassium channel toxin alpha-KTx 12.6
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at transcript level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily
Potassium channel toxin alpha-KTx 12.6
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion