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Peptide record

TPDB72079

Neurotoxin standard
65 amino acids
Basic Information
3D PDB MODEL
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TPDB72079
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 65-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MRCLPVFIILLLLASTAAVDVAGSKLKRRLERKPYQGSQAYVKKTAFGLRKCCKRHHGCHPCGRK
Physicochemical Analysis
C323H542N102O79S6
NW
LK
7310.85
10.78
18
2
25
+13
11.54
-0.192
87.08
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3230
44.18
14
Residue Composition
number
6
A
7
R
0
N
1
D
5
C
1
E
2
Q
5
G
3
H
2
I
8
L
8
K
1
M
2
F
3
P
3
S
2
T
0
W
2
Y
4
V
Amino Acid Distribution
A: 6 R: 7 N: 0 D: 1 C: 5 E: 1 Q: 2 G: 5 H: 3 I: 2 L: 8 K: 8 M: 1 F: 2 P: 3 S: 3 T: 2 W: 0 Y: 2 V: 4
Chemical Descriptors
65
C323H542N102O79S6
7310.85
10.78
+13
11.54
-0.192
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion channels. {ECO:0000305}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Probable neurotoxin with unknown target. Possibly targets ion channels..
Conotoxin Cal1.3 (Conotoxin Cal1.1a) (Conotoxin Cl1.3)
cone snail
Conotoxin T superfamily
Evidence at protein level
Amidation Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:21172372}.
Additional Detail Fields 7 fields
Amidation Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Conotoxin T superfamily
Conotoxin Cal1.3 (Conotoxin Cal1.1a) (Conotoxin Cl1.3)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:21172372}.
cone snail