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Peptide record

TPDB72076

Neurotoxin standard
107 amino acids
Basic Information
3D PDB MODEL
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TPDB72076
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 107-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MQLYTYLYLLVSLVTFYLILGTGTLGHGGALTERRSTDATALKPEPVLLQKSSARSTDDNGNDRLTQMKRILKKRGNKARGEEEVAKMAAELARENIAKGCKVNCYP
Physicochemical Analysis
C516H856N150O157S5
W
L
11833.68
9.84
18
11
42
+6
24.92
-0.402
88.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7575
64.01
29
Residue Composition
number
10
A
8
R
5
N
4
D
2
C
7
E
3
Q
9
G
1
H
3
I
15
L
9
K
3
M
1
F
3
P
5
S
9
T
0
W
5
Y
5
V
Amino Acid Distribution
A: 10 R: 8 N: 5 D: 4 C: 2 E: 7 Q: 3 G: 9 H: 1 I: 3 L: 15 K: 9 M: 3 F: 1 P: 3 S: 5 T: 9 W: 0 Y: 5 V: 5
Chemical Descriptors
107
C516H856N150O157S5
11833.68
9.84
+6
24.92
-0.402
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin is potent in the following order of preference: NR2B approximately NR2A/GRIN2A > NR2C/GRIN2C >> NR2D/GRIN2D. Induces sleep-like symptoms in young mice. Is a highly potent anticonvulsant compound. {ECO:0000269|PubMed:10604979}.

Target

glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin is potent in the following order of preference: NR2B approximately NR2A/GRIN2A > NR2C/GRIN2C >> NR2D/GRIN2D.
Conantokin-R (Con-R)
cone snail
Conotoxin B superfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10604979}.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Evidence at protein level
Conotoxin B superfamily
Conantokin-R (Con-R)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10604979}.
cone snail