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Peptide record

TPDB72066

Neurotoxin standard
84 amino acids
Basic Information
3D PDB MODEL
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TPDB72066
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 84-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MFSARLVLVFAVVLCIQLCNASWLDERAMTQEKRCNGKYQKCTSNSQCCDQKDYAKRKLRCLTQCDEGGCMKYKQCMFYAGTQK
Physicochemical Analysis
C413H666N120O122S14
HP
C
9713.40
8.63
14
7
30
+7
13.67
-0.412
58.10
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12085
124.42
33
Residue Composition
number
6
A
5
R
3
N
4
D
10
C
3
E
8
Q
4
G
0
H
1
I
7
L
9
K
4
M
3
F
0
P
4
S
4
T
1
W
4
Y
4
V
Amino Acid Distribution
A: 6 R: 5 N: 3 D: 4 C: 10 E: 3 Q: 8 G: 4 H: 0 I: 1 L: 7 K: 9 M: 4 F: 3 P: 0 S: 4 T: 4 W: 1 Y: 4 V: 4
Chemical Descriptors
84
C413H666N120O122S14
9713.40
8.63
+7
13.67
-0.412
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin that is probably only defensive (Probable). Acts as a voltage-gated potassium channel (Kv) inhibitor (By similarity). In vivo, induces a rapid increase in swimming speed on zebrafish larvae, as well as death which occurs between 2 and 18 hours later (PubMed:29424690). {ECO:0000250|UniProtKB:C0HJC4, ECO:0000269|PubMed:29424690, ECO:0000305|PubMed:29424690}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Nematostella vectensis (Starlet sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Neurotoxin that is probably only defensive (Probable). Acts as a voltage-gated potassium channel (Kv) inhibitor (By similarity).
Toxin NvePTx1
v1g239401
sea anemone
Sea anemone type 5 potassium channel toxin family
Evidence at protein level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: In unfertilized eggs and early post-fertilization stages, is expressed uniformly. In gastrulae, the expression becomes spatially-localized and seems to be absent from the oral and aboral poles. In planulae, the expression is clearly observed in the ectoderm in packed gland cells absent from the two body poles, and upon metamorphosis, the expression diminishes. There is two types of gland cells, one large and elongated and another small and round. This toxin is maternally deposited at both protein and RNA levels. {ECO:0000269|PubMed:29424690}.
Additional Detail Fields 8 fields
v1g239401
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 5 potassium channel toxin family
Toxin NvePTx1
TISSUE SPECIFICITY: In unfertilized eggs and early post-fertilization stages, is expressed uniformly. In gastrulae, the expression becomes spatially-localized and seems to be absent from the oral and aboral poles. In planulae, the expression is clearly observed in the ectoderm in packed gland cells absent from the two body poles, and upon metamorphosis, the expression diminishes. There is two types of gland cells, one large and elongated and another small and round. This toxin is maternally deposited at both protein and RNA levels. {ECO:0000269|PubMed:29424690}.
sea anemone