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Peptide record

TPDB72060

Neurotoxin standard
64 amino acids
Basic Information
3D PDB MODEL
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TPDB72060
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 64-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKSTLMTASVLILVLLSIVDYASVYAEFIDSEISLERQWINACFNVCMKISSDKKYCKYLCGKN
Physicochemical Analysis
C327H524N78O95S7
HP
S
7292.64
7.82
7
6
32
+1
4.04
0.405
108.12
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11710
160.57
22
Residue Composition
number
4
A
1
R
3
N
3
D
4
C
3
E
1
Q
1
G
0
H
6
I
7
L
6
K
3
M
2
F
0
P
8
S
2
T
1
W
4
Y
5
V
Amino Acid Distribution
A: 4 R: 1 N: 3 D: 3 C: 4 E: 3 Q: 1 G: 1 H: 0 I: 6 L: 7 K: 6 M: 3 F: 2 P: 0 S: 8 T: 2 W: 1 Y: 4 V: 5
Chemical Descriptors
64
C327H524N78O95S7
7292.64
7.82
+1
4.04
0.405
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potassium channel inhibitor (Kv). {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heterometrus petersii (Asian forest scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potassium channel inhibitor (Kv)..
Potassium channel toxin kappa-KTx 3.1 (HSP040C.1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 3 subfamily
Evidence at protein level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 3 subfamily
Potassium channel toxin kappa-KTx 3.1 (HSP040C.1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion