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Peptide record

TPDB72050

Neurotoxin standard
89 amino acids
Basic Information
3D PDB MODEL
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TPDB72050
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 89-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNLPTVLCIIALILGVRSAKNGFFTKLGKPIVCDDINFVGNYCQTKCVKAGANNGFCCQQKCYCLGLNDYAPTLQVADSSEKACQAMSG
Physicochemical Analysis
C413H663N111O123S11
HW
C
9504.14
8.01
8
5
36
+3
6.10
0.234
85.51
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4970
52.29
32
Residue Composition
number
8
A
1
R
7
N
4
D
9
C
1
E
5
Q
8
G
0
H
5
I
8
L
7
K
2
M
4
F
3
P
4
S
4
T
0
W
3
Y
6
V
Amino Acid Distribution
A: 8 R: 1 N: 7 D: 4 C: 9 E: 1 Q: 5 G: 8 H: 0 I: 5 L: 8 K: 7 M: 2 F: 4 P: 3 S: 4 T: 4 W: 0 Y: 3 V: 6
Chemical Descriptors
89
C413H663N111O123S11
9504.14
8.01
+3
6.10
0.234
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lychas mucronatus (Chinese swimming scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing..
Neurotoxin LmNaTx28
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Neurotoxin LmNaTx28
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion