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Peptide record

TPDB72041

Neurotoxin standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB72041
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 83-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MARQMMTVGCLILIVVLLDMMVPVFNTCPGQYDECGNGPEEGECCGTHNYCCKNACTTYHHCHGGRDAGKLLRSLKKLKLTTH
Physicochemical Analysis
C388H625N113O115S14
W
CGL
9161.76
7.49
13
7
28
+1
16.26
-0.098
72.77
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4970
54.25
26
Residue Composition
number
3
A
3
R
4
N
3
D
9
C
4
E
2
Q
9
G
5
H
2
I
9
L
5
K
5
M
1
F
3
P
1
S
7
T
0
W
3
Y
5
V
Amino Acid Distribution
A: 3 R: 3 N: 4 D: 3 C: 9 E: 4 Q: 2 G: 9 H: 5 I: 2 L: 9 K: 5 M: 5 F: 1 P: 3 S: 1 T: 7 W: 0 Y: 3 V: 5
Chemical Descriptors
83
C388H625N113O115S14
9161.76
7.49
+1
16.26
-0.098
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as a neurotoxin by inhibiting voltage-gated potassium channels (Kv). {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Iotyrris olangoensis (Sea snail) (Lophiotoma olangoensis)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Acts as a neurotoxin by inhibiting voltage-gated potassium channels (Kv)..
Turripeptide Lol11.1 (OL105)
other
Conopeptide I2-like superfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at transcript level
Conopeptide I2-like superfamily
Turripeptide Lol11.1 (OL105)
TISSUE SPECIFICITY: Expressed by the venom duct.
other