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Peptide record

TPDB72040

Neurotoxin standard
61 amino acids
Basic Information
3D PDB MODEL
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TPDB72040
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 61-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MHNYYKIVLIMVAFFAVIITFSNIQVEGAVCNLKRCQLSCRSLGLLGKCIGDKCECVKHGK
Physicochemical Analysis
C303H496N82O79S8
PW
CILKV
6808.25
8.86
10
3
28
+5
5.27
0.543
110.16
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
49.28
17
Residue Composition
number
3
A
2
R
3
N
1
D
6
C
2
E
2
Q
5
G
2
H
6
I
6
L
6
K
2
M
3
F
0
P
3
S
1
T
0
W
2
Y
6
V
Amino Acid Distribution
A: 3 R: 2 N: 3 D: 1 C: 6 E: 2 Q: 2 G: 5 H: 2 I: 6 L: 6 K: 6 M: 2 F: 3 P: 0 S: 3 T: 1 W: 0 Y: 2 V: 6
Chemical Descriptors
61
C303H496N82O79S8
6808.25
8.86
+5
5.27
0.543
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks small conductance calcium-activated potassium channels (KCNN, SK) (PubMed:9151979). Has also been shown to weakly inhibit Kv11.1/KCNH2/ERG1, Kv1.2/KCNA2, Kv1.3/KCNA3 and Kv2.1/KCNB1 voltage-gated potassium channels (PubMed:29483648). {ECO:0000269|PubMed:29483648, ECO:0000269|PubMed:9151979}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks small conductance calcium-activated potassium channels (KCNN, SK) (PubMed:9151979). Has also been shown to weakly inhibit Kv11.1/KCNH2/ERG1, Kv1.2/KCNA2, Kv1.3/KCNA3 and Kv2.1/KCNB1 voltage-gated potassium channels (PubMed:29483648)..
Potassium channel toxin alpha-KTx 5.3 (Neurotoxin BmP05) (Potassium ion channel blocker P05)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Evidence at protein level
Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9151979}.
Additional Detail Fields 7 fields
Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 05 subfamily
Potassium channel toxin alpha-KTx 5.3 (Neurotoxin BmP05) (Potassium ion channel blocker P05)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9151979}.
scorpion