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Peptide record

TPDB72034

Neurotoxin standard
92 amino acids
Basic Information
3D PDB MODEL
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TPDB72034
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 92-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKTILSMLIFVALFAAIVGNRWNLGYGIPHKQVKLPNGQLCKEPGDSCSKRDECCKADDQKTYSSGCAQTWSAMEGGFVRECYICAVESSMC
Physicochemical Analysis
C438H691N119O132S12
CGS
10120.74
7.49
11
9
35
+1
13.31
-0.079
70.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
15970
157.79
29
Residue Composition
number
7
A
3
R
3
N
4
D
8
C
5
E
4
Q
8
G
1
H
5
I
6
L
7
K
4
M
3
F
3
P
8
S
3
T
2
W
3
Y
5
V
Amino Acid Distribution
A: 7 R: 3 N: 3 D: 4 C: 8 E: 5 Q: 4 G: 8 H: 1 I: 5 L: 6 K: 7 M: 4 F: 3 P: 3 S: 8 T: 3 W: 2 Y: 3 V: 5
Chemical Descriptors
92
C438H691N119O132S12
10120.74
7.49
+1
13.31
-0.079
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent insecticidal toxin with probable ion channel impairing activity. In vivo, reversibly paralyzes all flies within 30 minutes, even at low dose (0.3 nmol/g). {ECO:0000269|PubMed:32398368}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Neurotoxin Ion channel impairing toxin
Potent insecticidal toxin with probable ion channel impairing activity. In vivo, reversibly paralyzes all flies within 30 minutes, even at low dose (0.3 nmol/g)..
U21-hexatoxin-Hi1a (U21-HXTX-Hi1a) (SF26 peptide)
spider
Neurotoxin 21 family
Evidence at protein level
3D-structure Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368}.
Additional Detail Fields 7 fields
3D-structure Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Neurotoxin 21 family
U21-hexatoxin-Hi1a (U21-HXTX-Hi1a) (SF26 peptide)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368}.
spider