TPDB

3D PDB MODEL

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TPDB ID TPDB72025

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 64-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MSTFIVVFLLLTAILCHAEHAIDETARGCNRLNKKCNSDADCCRYGERCISTGVNYYCRPDFGP

FASTA

>TPDB72025|Neurotoxin|length=64
MSTFIVVFLLLTAILCHAEHAIDETARGCNRLNKKCNSDADCCRYGERCISTGVNYYCRPDFGP

Formula C308H483N89O93S8

Absent Amino Acids QW

Common Amino Acids C

Mass 7177.24

PI 6.88

Basic Residues 9

Acidic Residues 7

Hydrophobic Residues 24

Net Charge -0

Boman Index 9.70

Hydrophobicity -0.042

Aliphatic Index 76.25

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 4845

Absorbance 280nm 67.51

Polar Residues 21

number

5

A

5

R

4

N

4

D

7

C

3

E

0

Q

4

G

2

H

4

I

5

L

2

K

1

M

3

F

2

P

3

S

4

T

0

W

3

Y

3

V

Amino Acid Distribution

A: 5 R: 5 N: 4 D: 4 C: 7 E: 3 Q: 0 G: 4 H: 2 I: 4 L: 5 K: 2 M: 1 F: 3 P: 2 S: 3 T: 4 W: 0 Y: 3 V: 3

Length

64

Formula

C308H483N89O93S8

Mass

7177.24

PI

6.88

Net Charge

-0

Boman Index

9.70

Hydrophobicity

-0.042

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Voltage-gated potassium channel (Kv) inhibitor (Ref.2). In addition it may increase intracellular calcium release through the activation of nuclear inositol 1,4,5-trisphosphate receptors (ITPR) of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells (By similarity). {ECO:0000250|UniProtKB:P0DM29, ECO:0000269|Ref.2}.

Target

Target or Channel voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)

Neurotoxin Type Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin

Mechanism

Voltage-gated potassium channel (Kv) inhibitor (Ref.2). In addition it may increase intracellular calcium release through the activation of nuclear inositol 1,4,5-trisphosphate receptors (ITPR) of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells (By similarity)..

Protein Name Neurotoxin lambda-MeuTx (Calcium channel toxin-like peptide-1)

Venom Taxon Group scorpion

Protein Family Scorpion calcin-like family

Protein Existence Evidence at protein level

Keywords 3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin Secreted Signal Toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.2}.

Keywords

3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin Secreted Signal Toxin

Neurotoxin_Type

Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin

Protein_Existence

Evidence at protein level

Protein_Family

Scorpion calcin-like family

Protein_Name

Neurotoxin lambda-MeuTx (Calcium channel toxin-like peptide-1)

Tissue_Specificity

TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.2}.

Venom_Taxon_Group

scorpion