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Peptide record

TPDB72021

Neurotoxin standard
74 amino acids
Basic Information
3D PDB MODEL
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TPDB72021
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 74-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MMFRVTSVGCFLLVIVLLHVAAVTSDDCRPEAAYCEYNEQCCIDKCCQASCSDACRTPGKRVHGHGLLRFFGQR
Physicochemical Analysis
C352H558N104O102S11
W
C
8231.60
7.47
11
7
29
+1
11.22
0.182
77.70
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3480
42.28
22
Residue Composition
number
6
A
6
R
1
N
4
D
9
C
3
E
3
Q
5
G
3
H
2
I
6
L
2
K
2
M
4
F
2
P
4
S
3
T
0
W
2
Y
7
V
Amino Acid Distribution
A: 6 R: 6 N: 1 D: 4 C: 9 E: 3 Q: 3 G: 5 H: 3 I: 2 L: 6 K: 2 M: 2 F: 4 P: 2 S: 4 T: 3 W: 0 Y: 2 V: 7
Chemical Descriptors
74
C352H558N104O102S11
8231.60
7.47
+1
11.22
0.182
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus ferrugineus (Cone snail)
Neurotoxin Ion channel impairing toxin
Conotoxin fe11.1
cone snail
Conotoxin I2 superfamily
Evidence at transcript level
Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Conotoxin I2 superfamily
Conotoxin fe11.1
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail