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Peptide record

TPDB72019

Neurotoxin standard
80 amino acids
Basic Information
3D PDB MODEL
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TPDB72019
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 80-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKLCLTFLLVLMILASVTGEKSSKHTLSRAARVKNRGPSFCKADEKPCKYHADCCNCCLGGICKPSTSWIGCSTNVFLTR
Physicochemical Analysis
C378H622N108O107S11
Q
CL
8744.42
9.02
14
4
28
+8
8.78
0.106
79.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
85.65
27
Residue Composition
number
5
A
4
R
3
N
2
D
9
C
2
E
0
Q
5
G
2
H
3
I
9
L
8
K
2
M
3
F
3
P
8
S
6
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 5 R: 4 N: 3 D: 2 C: 9 E: 2 Q: 0 G: 5 H: 2 I: 3 L: 9 K: 8 M: 2 F: 3 P: 3 S: 8 T: 6 W: 1 Y: 1 V: 4
Chemical Descriptors
80
C378H622N108O107S11
8744.42
9.02
+8
8.78
0.106
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Causes circular motion, convulsions, copious urination, rigid paralysis and death upon intracranial injection into mice. Causes unbalanced swimming, swimming in diagonal and vertical motion and death, when injected intraperitoneally into goldfish. L-Leu and D-Leu forms are active on both nerve and muscle. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Causes circular motion, convulsions, copious urination, rigid paralysis and death upon intracranial injection into mice.
Iota-conotoxin-like r11c (R11.4)
cone snail
Conotoxin I1 superfamily
Evidence at protein level
Cleavage on pair of basic residues D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin I1 superfamily
Iota-conotoxin-like r11c (R11.4)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail