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Peptide record

TPDB72015

Neurotoxin standard
65 amino acids
Basic Information
3D PDB MODEL
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TPDB72015
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 65-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKTSGTVYVFLLLLAFGIFTDISSACSEQMDDEDSYEVEKRGNACIEVCLQHTGNPAECDKACDK
Physicochemical Analysis
C305H478N78O105S7
W
DE
7142.03
4.06
6
12
24
-7
17.70
-0.137
73.54
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3230
45.23
20
Residue Composition
number
5
A
1
R
2
N
6
D
5
C
6
E
2
Q
4
G
1
H
3
I
5
L
4
K
2
M
3
F
1
P
5
S
4
T
0
W
2
Y
4
V
Amino Acid Distribution
A: 5 R: 1 N: 2 D: 6 C: 5 E: 6 Q: 2 G: 4 H: 1 I: 3 L: 5 K: 4 M: 2 F: 3 P: 1 S: 5 T: 4 W: 0 Y: 2 V: 4
Chemical Descriptors
65
C305H478N78O105S7
7142.03
4.06
-7
17.70
-0.137
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weakly inhibits the Kv7.1/KCNQ1 channel (10 uM of the toxin inhibits currents by 17.8%). {ECO:0000269|PubMed:22511981}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heterometrus petersii (Asian forest scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Weakly inhibits the Kv7.1/KCNQ1 channel (10 uM of the toxin inhibits currents by 17.8%)..
Potassium channel toxin kappa-KTx 2.7 (HSP053C.1) (Toxin HeTx203) (Toxin kappa-KTx 2.6)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily
Evidence at protein level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:20443192}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily
Potassium channel toxin kappa-KTx 2.7 (HSP053C.1) (Toxin HeTx203) (Toxin kappa-KTx 2.6)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:20443192}.
scorpion