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Peptide record

TPDB72008

Neurotoxin standard
83 amino acids
Basic Information
3D PDB MODEL
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TPDB72008
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 83-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKGQMIICLVLIALCMSVVVMAQNLRAEELEKANPKDERVRSFERNQKRACKDYLPKSECTQFRCRTSMKYKYTNCKKTCGTC
Physicochemical Analysis
C410H688N122O120S13
HW
K
9663.50
9.40
17
8
29
+9
23.35
-0.478
65.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4970
51.43
28
Residue Composition
number
5
A
7
R
4
N
2
D
8
C
6
E
4
Q
2
G
0
H
3
I
6
L
10
K
5
M
2
F
2
P
4
S
5
T
0
W
3
Y
5
V
Amino Acid Distribution
A: 5 R: 7 N: 4 D: 2 C: 8 E: 6 Q: 4 G: 2 H: 0 I: 3 L: 6 K: 10 M: 5 F: 2 P: 2 S: 4 T: 5 W: 0 Y: 3 V: 5
Chemical Descriptors
83
C410H688N122O120S13
9663.50
9.40
+9
23.35
-0.478
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Specifically, dose-dependently and potently blocks the voltage-gated potassium channel Kv1.1/KCNA1 (Ki=1.6 pM) (PubMed:16905168, PubMed:38102952). Moderately blocks potassium channel heterotetramers formed by 3 subunits of Kv1.1/KCNA1 and 1 subunit of Kv1.2/KCNA2 (Ki=56 nM) and weakly blocks those formed by 2 subunits of Kv1.1/KCNA1 and 2 subunits of Kv1.2/KCNA2 (Ki=14 nM). {ECO:0000269|PubMed:16905168, ECO:0000269|PubMed:38102952}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia erythraea (Sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Specifically, dose-dependently and potently blocks the voltage-gated potassium channel Kv1.1/KCNA1 (Ki=1.6 pM) (PubMed:16905168, PubMed:38102952). Moderately blocks potassium channel heterotetramers formed by 3 subunits of Kv1.1/KCNA1 and 1 subunit of Kv1.2/KCNA2 (Ki=56 nM) and weakly blocks those formed by 2 subunits of Kv1.1/KCNA1 and 2 subunits of Kv1.2/KCNA2 (Ki=14 nM)..
Kappa-actitoxin-Aer3a (Kappa-AITX-Aer3a) (AnerK) (Potassium channel toxin AETX K)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1a subfamily
Evidence at protein level
3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 1 potassium channel toxin family, Type 1a subfamily
Kappa-actitoxin-Aer3a (Kappa-AITX-Aer3a) (AnerK) (Potassium channel toxin AETX K)
sea anemone