Back to search

Peptide record

TPDB72005

Neurotoxin standard
90 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72005
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 90-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKTIPLLFLLFIYFECDGKFIRHKDESFYECGQLIGYQQYCVDACQAHGSKEKGYCKGMAPFGLPGGCYCPKLPSNRVKMCFGALESKCA
Physicochemical Analysis
C456H692N114O123S12
W
G
10123.92
8.01
13
8
35
+3
9.16
-0.068
64.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
9440
93.24
25
Residue Composition
number
5
A
2
R
1
N
3
D
9
C
5
E
4
Q
10
G
2
H
4
I
8
L
9
K
3
M
7
F
5
P
4
S
1
T
0
W
6
Y
2
V
Amino Acid Distribution
A: 5 R: 2 N: 1 D: 3 C: 9 E: 5 Q: 4 G: 10 H: 2 I: 4 L: 8 K: 9 M: 3 F: 7 P: 5 S: 4 T: 1 W: 0 Y: 6 V: 2
Chemical Descriptors
90
C456H692N114O123S12
10123.92
8.01
+3
9.16
-0.068
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Sodium channel (Nav) specific neurotoxin. Causes impairment of movement and mild paralysis in crickets at a dose of 0.5 ug per animal. A dose of 0.8 ug per cricket causes clear flaccid paralysis. A dose of 1.0 ug per cricket causes death within 2 hours. Is not toxic to mice at a dose of 100 ug per 20 g mouse weight. {ECO:0000269|PubMed:15606762}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anuroctonus phaiodactylus (Mafia scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Sodium channel (Nav) specific neurotoxin. Causes impairment of movement and mild paralysis in crickets at a dose of 0.5 ug per animal.
Phaiodotoxin
phtx
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:15606762}.
Additional Detail Fields 8 fields
phtx
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Phaiodotoxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:15606762}.
scorpion