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Peptide record

TPDB72004

Neurotoxin standard
80 amino acids
Basic Information
3D PDB MODEL
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TPDB72004
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 80-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MARLLVVSVGVFLAVIMLSSETMSLPAGENLPALTLFEAQNQLIGLSQEQRQCKKIGEHCYVADECCSKRCLFYAAKCVS
Physicochemical Analysis
C383H626N102O113S9
W
L
8756.34
6.77
8
7
37
-0
11.21
0.406
103.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
38.32
24
Residue Composition
number
8
A
3
R
2
N
1
D
6
C
6
E
5
Q
4
G
1
H
3
I
11
L
4
K
3
M
3
F
2
P
7
S
2
T
0
W
2
Y
7
V
Amino Acid Distribution
A: 8 R: 3 N: 2 D: 1 C: 6 E: 6 Q: 5 G: 4 H: 1 I: 3 L: 11 K: 4 M: 3 F: 3 P: 2 S: 7 T: 2 W: 0 Y: 2 V: 7
Chemical Descriptors
80
C383H626N102O113S9
8756.34
6.77
-0
11.21
0.406
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin that may modulate ions channels (other than those tested) (PubMed:31870846). In vivo, induces neurotoxic effects when injected into insects (tested on L.cuprina and A.domesticus) (PubMed:31870846). {ECO:0000269|PubMed:31870846}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Dolopus genitalis (Giant Australian assassin fly) (Asilus genitalis)
Neurotoxin Ion channel impairing toxin
Neurotoxin that may modulate ions channels (other than those tested) (PubMed:31870846). In vivo, induces neurotoxic effects when injected into insects (tested on L.cuprina and A.domesticus) (PubMed:31870846)..
U-Asilidin(1)-Dg12
insect
Asilidin-1 family
Evidence at protein level
3D-structure Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30400621, ECO:0000305|PubMed:31870846}.
Additional Detail Fields 7 fields
3D-structure Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Asilidin-1 family
U-Asilidin(1)-Dg12
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30400621, ECO:0000305|PubMed:31870846}.
insect