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Peptide record

TPDB71994

Neurotoxin standard
67 amino acids
Basic Information
3D PDB MODEL
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TPDB71994
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 67-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKNIAMKTTVVLTILLLSVLTAINADTMKKRSDYCSNDFCFFSCRRDRCARGDCENGKCVCKNCHLN
Physicochemical Analysis
C318H528N96O96S11
QPW
C
7584.94
8.52
12
6
24
+5
11.25
-0.082
75.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1990
26.24
24
Residue Composition
number
4
A
5
R
6
N
5
D
8
C
1
E
0
Q
2
G
1
H
3
I
6
L
6
K
3
M
3
F
0
P
4
S
5
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 4 R: 5 N: 6 D: 5 C: 8 E: 1 Q: 0 G: 2 H: 1 I: 3 L: 6 K: 6 M: 3 F: 3 P: 0 S: 4 T: 5 W: 0 Y: 1 V: 4
Chemical Descriptors
67
C318H528N96O96S11
7584.94
8.52
+5
11.25
-0.082
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels. {ECO:0000269|PubMed:29483648}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels..
Potassium channel toxin alpha-KTx
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17506894}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family
Potassium channel toxin alpha-KTx
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17506894}.
scorpion