TPDB

3D PDB MODEL

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TPDB ID TPDB71991

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 335-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MIIAVDGMGGDFAPELVVEGCIQAVKEYEGIHIIITGKKELIKNELDKREYNGNKIEILNAEEVISTNEAPVKAIRRKKDSSMVKALELVKEGKAQAVISAGSTGALMAGATFVLGRIKGINRVCLAPLLPGAKAPFMIADAGANVDCKAEYLVQFAMMGKVYFESVLGVKSPTVGLVNIGAEEEKGNELTKAAYKLLKDTDFNFIGNIEPRDIPRGEVNIAVCDGFIGNTVLKTYEGVASNLFSMLKKEIMASTRGKIGGALLKPVFKDFKKKFDYTEYGGSPFLGAKGICIKAHGSSDAKAFKNAIRQAKICYDKKIIEEIENNLGNLIENNI

FASTA

>TPDB71991|Neurotoxin|length=335
MIIAVDGMGGDFAPELVVEGCIQAVKEYEGIHIIITGKKELIKNELDKREYNGNKIEILNAEEVISTNEAPVKAIRRKKDSSMVKALELVKEGKAQAVISAGSTGALMAGATFVLGRIKGINRVCLAPLLPGAKAPFMIADAGANVDCKAEYLVQFAMMGKVYFESVLGVKSPTVGLVNIGAEEEKGNELTKAAYKLLKDTDFNFIGNIEPRDIPRGEVNIAVCDGFIGNTVLKTYEGVASNLFSMLKKEIMASTRGKIGGALLKPVFKDFKKKFDYTEYGGSPFLGAKGICIKAHGSSDAKAFKNAIRQAKICYDKKIIEEIENNLGNLIENNI

Formula C1620H2633N427O477S15

Absent Amino Acids W

Common Amino Acids K

Mass 36205.20

PI 8.45

Basic Residues 48

Acidic Residues 42

Hydrophobic Residues 147

Net Charge +4

Boman Index 82.22

Hydrophobicity -0.027

Aliphatic Index 97.58

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 13785

Absorbance 280nm 38.07

Polar Residues 63

number

34

A

9

R

20

N

14

D

6

C

28

E

4

Q

34

G

2

H

33

I

25

L

37

K

9

M

14

F

10

P

13

S

11

T

0

W

9

Y

23

V

Amino Acid Distribution

A: 34 R: 9 N: 20 D: 14 C: 6 E: 28 Q: 4 G: 34 H: 2 I: 33 L: 25 K: 37 M: 9 F: 14 P: 10 S: 13 T: 11 W: 0 Y: 9 V: 23

Length

335

Formula

C1620H2633N427O477S15

Mass

36205.20

PI

8.45

Net Charge

+4

Boman Index

82.22

Hydrophobicity

-0.027

Evidence 1 Activity

Source & Reference

Database Source NA