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Peptide record

TPDB71982

Neurotoxin standard
73 amino acids
Basic Information
3D PDB MODEL
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TPDB71982
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 73-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MTLTKSAVLILVLLLAFDNFADVQPGLITMGGGRLSNLLSKRVSIWFCASRTCSTPADCNPCTCESGVCVDWL
Physicochemical Analysis
C344H556N90O101S8
HY
L
7825.22
6.11
5
5
32
-0
-0.17
0.623
105.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11375
145.36
23
Residue Composition
number
5
A
3
R
3
N
4
D
6
C
1
E
1
Q
5
G
0
H
3
I
11
L
2
K
2
M
3
F
3
P
7
S
6
T
2
W
0
Y
6
V
Amino Acid Distribution
A: 5 R: 3 N: 3 D: 4 C: 6 E: 1 Q: 1 G: 5 H: 0 I: 3 L: 11 K: 2 M: 2 F: 3 P: 3 S: 7 T: 6 W: 2 Y: 0 V: 6
Chemical Descriptors
73
C344H556N90O101S8
7825.22
6.11
-0
-0.17
0.623
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable neurotoxin that inhibits ion channels. {ECO:0000305}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus litteratus (Lettered cone)
Neurotoxin Ion channel impairing toxin
Probable neurotoxin that inhibits ion channels..
Conotoxin Lt9a
cone snail
Conotoxin P superfamily
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:16908117}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Conotoxin P superfamily
Conotoxin Lt9a
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:16908117}.
cone snail