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Peptide record

TPDB71979

Neurotoxin standard
85 amino acids
Basic Information
3D PDB MODEL
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TPDB71979
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 85-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MQTAYWVMVMMMVMWITAPLSEGGKPKLIIRGLVPNDLTPQRILRSLISGRTYGIYDAKPPFSCAGLRGGCVLPPNLRPKFKEGR
Physicochemical Analysis
C429H695N117O109S8
H
GLP
9492.44
10.58
12
4
37
+8
6.47
0.032
90.59
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
15595
164.29
17
Residue Composition
number
4
A
7
R
2
N
2
D
2
C
2
E
2
Q
9
G
0
H
6
I
9
L
5
K
6
M
2
F
9
P
4
S
4
T
2
W
3
Y
5
V
Amino Acid Distribution
A: 4 R: 7 N: 2 D: 2 C: 2 E: 2 Q: 2 G: 9 H: 0 I: 6 L: 9 K: 5 M: 6 F: 2 P: 9 S: 4 T: 4 W: 2 Y: 3 V: 5
Chemical Descriptors
85
C429H695N117O109S8
9492.44
10.58
+8
6.47
0.032
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits both adult and fetal (alpha-1/beta-1/epsilon/delta and alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR). In vivo, it causes paralysis and death in mice and fish. {ECO:0000269|PubMed:17608455}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus parius (Cone snail)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits both adult and fetal (alpha-1/beta-1/epsilon/delta and alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR).
Alpha-conotoxin PrXA (Alpha-C-PrXA)
cone snail
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17608455}.
Additional Detail Fields 6 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Alpha-conotoxin PrXA (Alpha-C-PrXA)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17608455}.
cone snail