TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB71975

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 89-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MEIPKLLYIAVIAIGLSGSLTCATPLANPWGDPEAEANPEAKATAEATAEAIAEALAEPEPALPALPLLMFLFTLPALQHWIEKNWING

FASTA

>TPDB71975|Neurotoxin|length=89
MEIPKLLYIAVIAIGLSGSLTCATPLANPWGDPEAEANPEAKATAEATAEAIAEALAEPEPALPALPLLMFLFTLPALQHWIEKNWING

Formula C435H678N102O125S3

Absent Amino Acids R

Common Amino Acids A

Mass 9432.96

PI 3.97

Basic Residues 4

Acidic Residues 11

Hydrophobic Residues 47

Net Charge -8

Boman Index 11.23

Hydrophobicity 0.357

Aliphatic Index 111.12

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 17990

Absorbance 280nm 190.71

Polar Residues 14

number

18

A

0

R

4

N

1

D

1

C

10

E

1

Q

4

G

1

H

7

I

13

L

3

K

2

M

2

F

10

P

2

S

5

T

3

W

1

Y

1

V

Amino Acid Distribution

A: 18 R: 0 N: 4 D: 1 C: 1 E: 10 Q: 1 G: 4 H: 1 I: 7 L: 13 K: 3 M: 2 F: 2 P: 10 S: 2 T: 5 W: 3 Y: 1 V: 1

Length

89

Formula

C435H678N102O125S3

Mass

9432.96

PI

3.97

Net Charge

-8

Boman Index

11.23

Hydrophobicity

0.357

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Toxin that potently modulates mammalian voltage-gated sodium (Nav) channels, reducing the voltage threshold for activation and inhibiting channel inactivation. Shows activity on hNav1.6/SCN8A (EC(50)=176 nM), mNav1.7/SCN9A (EC(50)=102 nM) and hNav1.7 (EC(50)=154 nM). In vivo, causes spontaneous, gradual and long-lasting nocifensive behaviors by intraplantar injection in mice, as well as pronounced swelling of the injected paw. Does not have effect on insects (blowflies). {ECO:0000269|PubMed:38110035}.

Target

Target or Channel voltage-gated sodium channel (Nav)

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Pogonomyrmex maricopa (Maricopa harvester ant)

Neurotoxin Type Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin

Mechanism

Toxin that potently modulates mammalian voltage-gated sodium (Nav) channels, reducing the voltage threshold for activation and inhibiting channel inactivation. Shows activity on hNav1.6/SCN8A (EC(50)=176 nM), mNav1.7/SCN9A (EC(50)=102 nM) and hNav1.7 (EC(50)=154 nM).

Protein Name Myrmicitoxin(1)-Pm2a (MYRTX(1)-Pm2a)

Venom Taxon Group insect

Protein Family Formicidae venom clade 1 family

Protein Existence Evidence at protein level

Keywords Amidation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:38110035}.

Keywords

Amidation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin

Neurotoxin_Type

Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin

Protein_Existence

Evidence at protein level

Protein_Family

Formicidae venom clade 1 family

Protein_Name

Myrmicitoxin(1)-Pm2a (MYRTX(1)-Pm2a)

Tissue_Specificity

TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:38110035}.

Venom_Taxon_Group

insect